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Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues
RSC Advances ( IF 3.9 ) Pub Date : 2020-4-1 , DOI: 10.1039/d0ra01574a Mohammad Reza Zamani Kouhpanji 1, 2 , Bethanie J H Stadler 1, 3
RSC Advances ( IF 3.9 ) Pub Date : 2020-4-1 , DOI: 10.1039/d0ra01574a Mohammad Reza Zamani Kouhpanji 1, 2 , Bethanie J H Stadler 1, 3
Affiliation
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The unmet demand for cheap, accurate, and fast multiplexing of biomarkers has urged nanobiotechnology to prioritize the invention of new biomarkers that make feasible the remote detection, identification, and quantification of biological units, such as regenerative tissues. Here, we introduce a novel approach that highlights magnetic nanowires (MNWs) with such capabilities. This method employs the stable magnetization states of MNWs as a unique characteristic that can be realized by projecting the MNWs' switching field on the backward field (PHb), also known as the irreversible switching field. Experimentally, several types of MNWs were directly synthesized inside polycarbonate tissues and their PHb characteristics were measured and analyzed. Our results show that the PHb gives an excellent identification and quantification characteristic for demultiplexing MNWs embedded in these tissues. Furthermore, this method significantly improves the characterization speed by a factor of 50×–100× that makes it superior to the current state of the art that ceased the progression of magnetic nanoparticles in multiplexing/demultiplexing applications.
中文翻译：
投影法作为磁性富集生物组织复用/解复用探针
对廉价、准确和快速的生物标志物多重分析的需求尚未得到满足，这促使纳米生物技术优先考虑新生物标志物的发明，使生物单位（例如再生组织）的远程检测、识别和定量成为可能。在这里，我们介绍了一种新颖的方法，突出了具有此类功能的磁性纳米线（MNW）。该方法利用 MNW 的稳定磁化状态作为独特的特性，可以通过将 MNW 的切换场投影到反向场 ( P Hb )（也称为不可逆切换场）上来实现。实验上，直接在聚碳酸酯组织内合成了几种类型的 MNW，并测量和分析了它们的P Hb特性。我们的结果表明， P Hb为嵌入这些组织中的 MNW 的解复用提供了出色的识别和定量特性。此外，该方法将表征速度显着提高了 50×–100× 倍，这使其优于当前在多路复用/解复用应用中停止磁性纳米粒子进展的现有技术。
更新日期：2020-04-01
中文翻译：
投影法作为磁性富集生物组织复用/解复用探针
对廉价、准确和快速的生物标志物多重分析的需求尚未得到满足，这促使纳米生物技术优先考虑新生物标志物的发明，使生物单位（例如再生组织）的远程检测、识别和定量成为可能。在这里，我们介绍了一种新颖的方法，突出了具有此类功能的磁性纳米线（MNW）。该方法利用 MNW 的稳定磁化状态作为独特的特性，可以通过将 MNW 的切换场投影到反向场 ( P Hb )（也称为不可逆切换场）上来实现。实验上，直接在聚碳酸酯组织内合成了几种类型的 MNW，并测量和分析了它们的P Hb特性。我们的结果表明， P Hb为嵌入这些组织中的 MNW 的解复用提供了出色的识别和定量特性。此外，该方法将表征速度显着提高了 50×–100× 倍，这使其优于当前在多路复用/解复用应用中停止磁性纳米粒子进展的现有技术。
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