Abstract Aims To investigate associations of life‐time hazardous and binge drinking with biomarkers of cardiometabolic health, liver function, cardiovascular disease (CVD) and mortality. Design Prospective cohort study with median follow‐up time to CVD incidence of 4.5 years. Setting London, UK: civil servants within the Whitehall II Study. Participants A total of 4820 drinkers aged 59–83 years with biological measurements during the 2011–12 survey. Measurements Hazardous drinking was defined as having an AUDIT‐C score ≥ 5 calculated at each decade of life, forming the following groups: never hazardous drinker, former early (stopping before age 50), former later (stopping after age 50), current hazardous drinker and consistent hazardous drinker (hazardous drinker at each decade of life). Findings More than half the sample had been hazardous drinkers at some point during their life‐time, comprising former early (< age 50) (19%), former later (≥ age 50) (11%), current (21%) and consistent hazardous drinker (AUDIT‐C ≥ 5 across life (5%). After adjusting for covariates, waist circumference was larger with more persistent hazardous drinking (e.g. compared with never hazardous drinkers, former early had increased waist circumference by 1.17 cm [95% confidence interval (CI) = 0.25‐2.08]; former later by 1.88 cm (CI = 0.77–2.98); current by 2.44 cm (CI = 1.50–3.34) and consistent hazardous drinker by 3.85 cm (CI = 2.23–5.47). Current hazardous drinkers had higher systolic blood pressure (2.44 mmHg, CI = 1.19–3.68) and fatty liver index scores (4.05 mmHg, CI = 2.92–5.18) than never hazardous drinkers. Current hazardous drinkers [hazard ratio (HR) = 2.75, CI = 1.44–5.22) had an elevated risk of stroke, and former later hazardous drinkers had an elevated risk of non‐CVD mortality (HR = 1.93, CI = 1.19–3.14) than never hazardous drinkers. Life‐time binge drinking was associated with larger waist circumferences and poorer liver function compared with never binge drinkers. Conclusion Hazardous drinking may increase cardiometabolic risk factors; this is made worse by persistent hazardous drinking throughout life, particularly in relation to weight gain, suggesting benefits of early intervention.

中文翻译：

---

老年人终生危险饮酒及其对健康的危害：Whitehall II 前瞻性队列研究的结果


摘要 目的 研究终生危险饮酒和酗酒与心脏代谢健康、肝功能、心血管疾病 (CVD) 和死亡率等生物标志物的关系。设计前瞻性队列研究，CVD 发病率中位随访时间为 4.5 年。以英国伦敦为背景：白厅 II 研究中的公务员。参与者 2011-12 年调查期间共有 4820 名年龄在 59-83 岁的饮酒者进行了生物测量。测量 危险饮酒被定义为每十年计算一次 AUDIT-C 评分 ≥ 5，分为以下几组：从不危险饮酒者、以前较早饮酒者（50 岁之前停止）、以前较晚饮酒者（50 岁之后停止）、当前危险饮酒者饮酒者和一贯的危险饮酒者（每十年都有危险饮酒者）。结果 超过一半的样本在其一生中的某个时刻曾是危险饮酒者，其中包括以前的早期饮酒者（< 50 岁）（19%）、以前的晚期饮酒者（≥ 50 岁）（11%）、现在的饮酒者（21%）持续危险饮酒者（一生中 AUDIT-C ≥ 5 (5%)。调整协变量后，持续危险饮酒者腰围较大（例如，与从不危险饮酒者相比，前者早期腰围增加了 1.17 厘米 [95 % 置信区间 (CI) = 0.25-2.08]；前者后者 1.88 cm (CI = 0.77–2.98)；当前 2.44 cm (CI = 1.50–3.34)，持续危险饮酒者 3.85 cm (CI = 2.23–5.47)当前危险饮酒者的收缩压（2.44 mmHg，CI = 1.19–3.68）和脂肪肝指数评分（4.05 mmHg，CI = 2.92–5.18）高于当前危险饮酒者[风险比（HR）= 2.75。 ，CI = 1.44–5。22) 的中风风险较高，而且以前的危险饮酒者与从不危险饮酒的人相比，非心血管疾病死亡的风险较高（HR = 1.93，CI = 1.19–3.14）。与从不酗酒的人相比，终生酗酒与腰围较大和肝功能较差有关。结论 有害饮酒可能增加心脏代谢危险因素；终生持续危险饮酒会使情况变得更糟，特别是在体重增加方面，这表明早期干预的好处。