Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC‐EORP Heart Failure Long‐Term Registry,European Journal of Heart Failure

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Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC‐EORP Heart Failure Long‐Term Registry
European Journal of Heart Failure ( IF 18.2 ) Pub Date : 2020-04-01 , DOI: 10.1002/ejhf.1796
Chris J Kapelios ₁ , Cécile Laroche ₂ , Maria G Crespo-Leiro ₃ , Stefan D Anker ₄ , Andrew J S Coats ₅ , Beatria Díaz-Molina ₆ , Gerasimos Filippatos ₇ , Mitja Lainscak ₈ , Aldo P Maggioni _{2,

9} , Theresa McDonagh ₁₀ , Alexandre Mebazaa ₁₁ , Marco Metra ₁₂ , Brenda Moura ₁₃ , Wilfried Mullens ₁₄ , Massimo F Piepoli ₁₅ , Giuseppe M C Rosano ₅ , Frank Ruschitzka ₁₆ , Petar M Seferovic ₁₇ , Lars H Lund ₁₈ ,

Affiliation

Department of Cardiology, Laiko General Hospital, Athens, Greece.
EURObservational Research Programme, European Society of Cardiology, Sophia-Antipolis, France.
Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco, Complexo Hospitalario Universitario A Coruna, CHUAC, INIBIC, UDC, CIBERCV, La Coruna, Spain.
Department of Cardiology (CVK), Berlin Institute of Health Center for Regenerative Therapies (BCRT); German Centre for Cardiovascular Research (DZHK) Partner Site Berlin; Charité Universitätsmedizin Berlin, Berlin, Germany.
IRCCS, San Raffaele Pisana, Rome, Italy.
Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco, Hospital Universitario Central de Asturias, Oviedo, Spain.
Department of Cardiology, School of Medicine, University of Cyprus & Heart Failure Unit, University Hospital Attikon, National and Kapodistrian Univeristy of Athens, Athens, Greece.
Division of Cardiology, Murska Sobota, Murska Sobota and Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
ANMCO Research Center, Florence, Italy.
King's College Hospital, London, UK.
Department of Anesthesia-Burn-Critical Care, UMR 942 Inserm - MASCOT, University of Paris; APHP Saint Louis Lariboisière University Hospitals, Paris, France.
Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Department of Cardiology, Hospital Militar, Porto, Cintesis- Faculty of Medicine, University of Porto, Porto, Portugal.
Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium; Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.
Heart Failure Unit, Cardiac Department, G. da Saliceto Hospital, AUSL, Piacenza, Italy.
Clinic of Cardiology, University Hospital, Zürich, Switzerland.
University of Belgrade Faculty of Medicine, Belgrade, Serbia.
Unit of Cardiology, Department of Medicine, Karolinska Institutet, and Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden.

Guidelines recommend down‐titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down‐titration and association between dose changes and outcomes.

中文翻译：

慢性心力衰竭的loop利尿剂剂量变化与预后之间的关联：ESC-EORP心力衰竭长期注册中心的观察

指南建议在达到尿毒症血症后滴定loop利尿剂（LD）。在心力衰竭（HF）的门诊患者中，我们调查了日常心脏病学实践中的LD剂量变化，与指南建议的一致性，LD滴定成功的预测因素以及剂量变化与结果之间的关联。

更新日期：2020-04-01

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