Cobalt‐Catalyzed Reductive Carboxylation of Aryl Bromides with Carbon Dioxide,Advanced Synthesis & Catalysis

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Cobalt‐Catalyzed Reductive Carboxylation of Aryl Bromides with Carbon Dioxide
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-03-31 , DOI: 10.1002/adsc.202000301
Wei Hang ₁ , Yaping Yi ₁ , Chanjuan Xi _{1,

2}

Affiliation

Cobalt‐catalyzed reductive carboxylation of aryl bromides with carbon dioxide has been developed. The reaction proceeded under one atm pressure of CO₂ at 40 °C in the presence of cobalt iodide/2,2′‐bipyridine catalysts and zinc dust as a reducing reagent. Various aryl bromides could be converted to the corresponding carboxylic acids in good to high yields. Preliminary mechanistic experiments ruled out intervention of intermediate organozinc species for carboxylation with CO₂, thus suggesting a direct CO₂ insertion into the corresponding ArCoBr species.

中文翻译：

二氧化碳催化的钴催化芳基溴化物的还原羧化

已经开发了用二氧化碳进行钴催化的芳基溴化物的还原羧化反应。该反应在碘化钴/ 2,2'-联吡啶催化剂和锌粉作为还原剂的存在下于40°C的1个大气压的CO ₂大气压下进行。各种芳基溴化物都可以良好或高收率地转化为相应的羧酸。初步的机械实验排除了中间有机锌物质对CO ₂进行羧化的干预，因此建议将CO ₂直接插入相应的ArCoBr物质中。

更新日期：2020-03-31

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