Hierarchical binding of copperII to N-truncated Aβ4-16 peptide.,Metallomics

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Hierarchical binding of copperII to N-truncated Aβ4-16 peptide.
Metallomics ( IF 2.9 ) Pub Date : 2020-04-01 , DOI: 10.1039/c9mt00299e
Xiangyu Teng ₁ , Ewelina Stefaniak , Paul Girvan , Radosław Kotuniak , Dawid Płonka , Wojciech Bal , Liming Ying

Affiliation

N-Truncated Aβ4-42 displays a high binding affinity with CuII. A mechanistic scheme of the interactions between Aβ4-42 and CuII has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ4-42 during neurotransmission.

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