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Hierarchical binding of copperII to N-truncated Aβ4-16 peptide.
Metallomics ( IF 2.9 ) Pub Date : 2020-04-01 , DOI: 10.1039/c9mt00299e
Xiangyu Teng 1 , Ewelina Stefaniak , Paul Girvan , Radosław Kotuniak , Dawid Płonka , Wojciech Bal , Liming Ying
Affiliation  

N-Truncated Aβ4-42 displays a high binding affinity with CuII. A mechanistic scheme of the interactions between Aβ4-42 and CuII has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ4-42 during neurotransmission.

中文翻译:

铜II与N-截短的Aβ4-16肽的层次结合。

N-截短的Aβ4-42显示与CuII的高结合亲和力。已经使用荧光方法提出了Aβ4-42和CuII之间相互作用的机制方案。确定了不同转换步骤的时间尺度。这种动力学机制表明神经传递过程中Aβ4-42的潜在突触功能。
更新日期:2020-04-01
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