“Thalamocortical anatomical connectivity in schizophrenia and psychotic bipolar disorder” by Sheffield et al¹ is a welcome addition to the growing literature on thalamocortical functional dysconnectivity in schizophrenia. Using diffusion-weighted imaging, Sheffield et al¹ give anatomical teeth to the functional findings. Furthermore, they expand on the functional literature by studying people with schizophrenia and psychotic bipolar disorder, and go even further, by studying patients who are in the early stages of the disorders. In a set of findings that nicely parallel the functional connectivity data, the authors report similar patterns for anatomical thalamocortical dysconnectivity in psychosis: lower prefrontal cortical-thalamic connectivity and greater somatosensory-thalamic anatomical connectivity were present in both schizophrenia and psychotic bipolar disorder, both early and later in the illnesses.

中文翻译：

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整个疾病过程中精神病的解剖学脱节：扩展和扩展功能脱节文献


Sheffield 等人的“精神分裂症和精神病性双相情感障碍中的丘脑皮质解剖连接性” ¹是对精神分裂症中丘脑皮质功能性连接障碍的文献的一个受欢迎的补充。 Sheffield 等人¹使用扩散加权成像给出了牙齿的解剖学结果和功能发现。此外，他们还通过研究精神分裂症和精神病性双相情感障碍患者来扩展功能性文献，并进一步研究处于疾病早期阶段的患者。在一组与功能连接数据非常相似的研究结果中，作者报告了精神病中解剖丘脑皮质连接障碍的相似模式：精神分裂症和精神病性双相情感障碍都存在较低的前额叶皮质-丘脑连接性和较高的体感-丘脑解剖连接性。以及后来的疾病。