Prevalence and Sequelae of Cryptococcal Antigenemia in Antiretroviral Therapy–Experienced Populations: An Evaluation of Reflex Cryptococcal Antigen Screening in Botswana,Clinical Infectious Diseases

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Prevalence and Sequelae of Cryptococcal Antigenemia in Antiretroviral Therapy–Experienced Populations: An Evaluation of Reflex Cryptococcal Antigen Screening in Botswana
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2020-04-01 , DOI: 10.1093/cid/ciaa356
William J Hurt ₁ , Mark W Tenforde _{1,

2,

3} , Mooketsi Molefi ₄ , Hannah K Mitchell _{1,

5} , Thandi Milton ₁ , Martin S Azama ₆ , Irene Goercke ₄ , Fredah Mulenga ₇ , Nametso Tlhako ₁ , Katlego Tsholo ₁ , Tuhina Srivastava ₈ , Tshepo B Leeme _{1,

9} , Godfrey Simoonga ₆ , Charles Muthoga _{1,

9} , Kwana Lechiile _{1,

9} , Madisa Mine ₇ , Joseph N Jarvis _{1,

9,

10}

Affiliation

Botswana University of Pennsylvania Partnership, Gaborone, Botswana.
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA.
University of Botswana, Gaborone, Botswana.
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Ministry of Health and Wellness, Gaborone, Botswana.
Botswana National Health Laboratory, Gaborone, Botswana.
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Evidence to inform cryptococcal antigen (CrAg)–screening guidelines among ART-experienced populations is lacking. We performed a study evaluating the utility of reflex CrAg screening in Gaborone, Botswana.

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