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Synthesis of Conductive Carbon Aerogels Decorated with β-Tricalcium Phosphate Nanocrystallites.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-04-01 , DOI: 10.1038/s41598-020-62822-1 Atakan Tevlek 1 , Abdulraheem M N Atya 1 , Muhannad Almemar 1 , Memed Duman 2 , Dincer Gokcen 3 , Alexey Y Ganin 4 , Humphrey H P Yiu 5 , Halil M Aydin 1, 6
Scientific Reports ( IF 3.8 ) Pub Date : 2020-04-01 , DOI: 10.1038/s41598-020-62822-1 Atakan Tevlek 1 , Abdulraheem M N Atya 1 , Muhannad Almemar 1 , Memed Duman 2 , Dincer Gokcen 3 , Alexey Y Ganin 4 , Humphrey H P Yiu 5 , Halil M Aydin 1, 6
Affiliation
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There has been substantial interest in research aimed at conductive carbon-based supports since the discovery that the electrical stimulus can have dramatic effect on cell behavior. Among these carbon-aerogels decorated with biocompatible polymers were suggested as future materials for tissue engineering. However, high reaction temperatures required for the synthesis of the aerogels tend to impair the stability of the polymeric networks. Herein, we report a synthetic route towards carbon-aerogel scaffolds decorated with biocompatible ceramic nanoparticles of tricalcium phosphate. The composites can be prepared at temperature as high as 1100 °C without significant effect on the morphology of the composite which is comparable with the original aerogel framework. Although the conductivity of the composites tends to decrease with the increasing ceramic content the measured conductivity values are similar to those previously reported on polymer-functionalized carbon-aerogels. The cell culture study revealed that the developed constructs support cell proliferation and provide good cell attachment suggesting them as potentially good candidates for tissue-engineering applications.
中文翻译：
β-磷酸三钙纳米晶体修饰的导电碳气凝胶的合成。
自从发现电刺激可以对细胞行为产生巨大影响以来，人们对基于导电碳基载体的研究已经引起了极大兴趣。在这些用生物相容性聚合物装饰的碳气凝胶中，被建议作为组织工程的未来材料。然而，气凝胶合成所需的高反应温度倾向于损害聚合物网络的稳定性。在本文中，我们报告了一条合成路线，该路线指向装饰有磷酸三钙生物相容性陶瓷纳米粒子的碳气凝胶支架。可以在高达1100°C的温度下制备复合材料，而对复合材料的形态没有明显影响，这与原始的气凝胶骨架相当。尽管随着陶瓷含量的增加，复合材料的电导率趋于降低，但测得的电导率值与先前在聚合物功能化碳气凝胶上报道的电导率值相似。细胞培养研究表明，开发的构建体支持细胞增殖并提供良好的细胞附着性，表明它们是组织工程应用的潜在良好候选者。
更新日期：2020-04-01
中文翻译：
β-磷酸三钙纳米晶体修饰的导电碳气凝胶的合成。
自从发现电刺激可以对细胞行为产生巨大影响以来，人们对基于导电碳基载体的研究已经引起了极大兴趣。在这些用生物相容性聚合物装饰的碳气凝胶中，被建议作为组织工程的未来材料。然而，气凝胶合成所需的高反应温度倾向于损害聚合物网络的稳定性。在本文中，我们报告了一条合成路线，该路线指向装饰有磷酸三钙生物相容性陶瓷纳米粒子的碳气凝胶支架。可以在高达1100°C的温度下制备复合材料，而对复合材料的形态没有明显影响，这与原始的气凝胶骨架相当。尽管随着陶瓷含量的增加，复合材料的电导率趋于降低，但测得的电导率值与先前在聚合物功能化碳气凝胶上报道的电导率值相似。细胞培养研究表明，开发的构建体支持细胞增殖并提供良好的细胞附着性，表明它们是组织工程应用的潜在良好候选者。
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