Surface Enhanced Raman Scattering (SERS) has been widely applied in many research fields such as biological detection and chemical analysis. However, for the common Au nanoparticles, it’s too hard to guarante the three aspects: the great enhanced effect, the controllable aggregation and the uniformity of nanoparticles, the environmental friendliness and biocompatibility of nanoparticles. In this paper, phytate acid (IP6)-coated Au nanoparticles (IP6@Au NPs) are more stable and have a higher enhancement factor than Au nanoparticles. In order to achieve the uniformity of the spherical IP6-coated@Au nanoparticles (IP6@Au NPs), IP6 was used as a soft template. In the presence of IP6, IP6@Ag nanoparticles were first synthesized by reducing AgNO₃ with trisodium citrate, then IP6@Au NPs were obtained by reducing HAuCl₄ with Ag nanoparticles. The IP6@Au NPs exhibit excellent Raman signal enhancement by using p-aminothiophenol (4-ATP) as the probe molecules. The effects of Fe³⁺ on the performance of IP6@Au NPs SERS substrates were also studied. The results show that SERS has the best enhancement effect when adding proper amount of Fe³⁺ (0.56 PPM), and the limit of detection was 10⁻⁷ M 4-ATP.

表面增强拉曼散射（SERS）已广泛应用于许多研究领域，例如生物检测和化学分析。但是，对于普通的金纳米粒子，很难保证这三个方面：增强的效果，纳米粒子可控的聚集和均匀性，纳米粒子的环境友好性和生物相容性。在本文中，植酸（IP6）包覆的Au纳米颗粒（IP6 @ Au NPs）比Au纳米颗粒更稳定并且具有更高的增强因子。为了获得球形IP6涂层金Au纳米颗粒（IP6Au NPs）的均匀性，将IP6用作软模板。在IP6存在下，首先通过还原AgNO ₃合成IP6 @ Ag纳米颗粒用柠檬酸三钠，然后通过用银纳米颗粒还原HAuCl ₄获得IP6 @ Au NP 。通过使用对氨基硫酚（4-ATP）作为探针分子，IP6 @ Au NP表现出出色的拉曼信号增强。还研究了Fe ³⁺对IP6 @ Au NPs SERS基底性能的影响。结果表明，当添加适量的Fe ³⁺（0.56 PPM）时，SERS的增强效果最佳，检出限为10 ^-7  M 4-ATP。