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Inflammatory markers are associated with psychomotor slowing in patients with schizophrenia compared to healthy controls.
npj Schizophrenia ( IF 5.7 ) Pub Date : 2020-04-01 , DOI: 10.1038/s41537-020-0098-4
David R Goldsmith 1 , Nicholas Massa 2, 3 , Bradley D Pearce 3 , Evanthia C Wommack 1 , Alaaeddin Alrohaibani 2 , Neha Goel 2 , Bruce Cuthbert 1, 2 , Molly Fargotstein 2 , Jennifer C Felger 1 , Ebrahim Haroon 1 , Andrew H Miller 1 , Erica Duncan 1, 2
Affiliation  

Patients with schizophrenia exhibit psychomotor deficits that are associated with poor functional outcomes. One pathway that may be associated with psychomotor slowing is inflammation. Inflammatory markers have been shown to be elevated in patients with schizophrenia and are associated with psychomotor deficits in both animal and human studies. Forty-three patients with schizophrenia and 29 healthy controls were recruited and underwent a battery of psychomotor tasks. The following immune measures in peripheral blood were assayed: IL-6, IL-1 beta, IL-10, TNF, MCP-1, IL-6sr, IL-1RA, and TNFR2. Generalized linear models were used to determine which immune markers, in addition to their interaction with diagnosis, were associated with performance on the psychomotor tasks. As expected, patients with schizophrenia demonstrated slower performance compared with healthy controls on the finger tapping test (FTT, tested on dominant and non-dominant hands), trail making test (TMT), and symbol coding test (SC). Interactive effects with diagnosis were found for TNF, IL-10, IL-6sr, and TNFR2 for the FTT (dominant), IL-10 and IL-6sr for FTT (non-dominant), TNF and IL-10 for TMT and TNF, IL-10, IL-6sr, TNFR2, and IL-1RA for SC. The results of this study provide evidence that peripheral inflammatory markers contribute to psychomotor slowing in patients with schizophrenia. These data are consistent with a growing literature, demonstrating that inflammation may target the basal ganglia to contribute to psychomotor deficits as is seen in other psychiatric disorders such as depression. These data also indicate that psychomotor speed may be a relevant construct to target in studies of the immune system in schizophrenia.

中文翻译:

与健康对照相比,炎症标志物与精神分裂症患者的精神运动减慢有关。

精神分裂症患者表现出与不良功能结果相关的精神运动缺陷。可能与精神运动减慢相关的一种途径是炎症。在动物和人类研究中,炎症标志物已被证明在精神分裂症患者中升高,并且与精神运动缺陷有关。招募了 43 名精神分裂症患者和 29 名健康对照者,并接受了一系列精神运动任务。测定了外周血中的以下免疫指标:IL-6、IL-1β、IL-10、TNF、MCP-1、IL-6sr、IL-1RA 和 TNFR2。广义线性模型用于确定哪些免疫标志物,除了它们与诊断的相互作用外,还与精神运动任务的表现有关。正如预期的那样,与健康对照组相比,精神分裂症患者在手指敲击测试(FTT,在优势手和非优势手上进行测试)、追踪测试 (TMT) 和符号编码测试 (SC) 表现出较慢的表现。FTT(显性)的 TNF、IL-10、IL-6sr 和 TNFR2、FTT(非显性)的 IL-10 和 IL-6sr、TMT 和 TNF 的 TNF 和 IL-10 与诊断有交互作用、IL-10、IL-6sr、TNFR2和IL-1RA用于SC。这项研究的结果提供了证据,表明外周炎症标志物有助于精神分裂症患者的精神运动减慢。这些数据与越来越多的文献一致,表明炎症可能以基底神经节为靶点,导致精神运动障碍,如抑郁症等其他精神疾病。
更新日期:2020-04-01
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