Regulation and function of capicua in mammals.,Experimental & Molecular Medicine

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Regulation and function of capicua in mammals.
Experimental & Molecular Medicine ( IF 9.5 ) Pub Date : 2020-04-01 , DOI: 10.1038/s12276-020-0411-3
Yoontae Lee _{1,

2}

Affiliation

Capicua (CIC) is an evolutionarily conserved transcription factor. CIC contains a high-mobility group (HMG) box that recognizes specific DNA sequences to regulate the expression of various target genes. CIC was originally identified in Drosophila melanogaster as a transcriptional repressor that suppresses the receptor tyrosine kinase signaling pathway. This molecule controls normal organ growth and tissue patterning as well as embryogenesis in Drosophila. Recent studies have also demonstrated its extensive functions in mammals. For example, CIC regulates several developmental and physiological processes, including lung development, abdominal wall closure during embryogenesis, brain development and function, neural stem cell homeostasis, T cell differentiation, and enterohepatic circulation of bile acids. CIC is also associated with the progression of various types of cancer and neurodegeneration in spinocerebellar ataxia type-1, systemic autoimmunity, and liver injury. In this review, I provide a broad overview of our current understanding of the regulation and functions of CIC in mammals and discuss future research directions.

中文翻译：

哺乳动物 Capicua 的调节和功能。

Capicua (CIC) 是一种进化上保守的转录因子。CIC包含一个高迁移率组（HMG）盒，可以识别特定的DNA序列来调节各种靶基因的表达。CIC 最初在果蝇中被鉴定为转录抑制因子，可抑制受体酪氨酸激酶信号通路。该分子控制果蝇的正常器官生长和组织模式以及胚胎发生。最近的研究也证明了其在哺乳动物中的广泛功能。例如，CIC 调节多种发育和生理过程，包括肺发育、胚胎发生过程中的腹壁闭合、大脑发育和功能、神经干细胞稳态、T 细胞分化和胆汁酸的肠肝循环。CIC 还与各种癌症的进展以及 1 型脊髓小脑共济失调、全身性自身免疫和肝损伤中的神经变性有关。在这篇综述中，我对我们目前对哺乳动物中 CIC 的调节和功能的理解进行了广泛的概述，并讨论了未来的研究方向。

更新日期：2020-04-24

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