This systematic investigation assessed the potential applications of microfluidic devices in producing a uniform size distribution of polycaprolactone (PCL) nanoparticles by applying the liquid non-solvent precipitation process. Five arrangements of microfluidic devices are fabricated with different designs. The effects of different operational and geometrical factors such as flow rate ratio (FRR), total flow rate (TFR), mixing channel width, mixing channel length, and confluence angles of the inlet channels are investigated on the size, polydispersity index (PDI), and the size distribution of PCL particles. Further, a study was performed to enhance the production throughput of PCL nanoparticles. The mean size of nanoparticles is precisely controlled within the range of 40–370 nm with PDI values of 0.2–0.37. According to the results, the optimal conditions for rapid production of nanoparticles with a size smaller than 200 nm and PDI ≤ 0.31 are obtained at FRR of 8, TFR of 70 ml h⁻¹, channel width of 200 μm, channel length of 20 mm, and the confluence angle of 60^o. Furthermore, the microfluidic device with a wider channel width of 600 μm provided a higher productivity rate of the PCL nanoparticles with a similar size and lower PDI than those obtained by other widths.

这项系统的研究评估了通过应用液体非溶剂沉淀工艺，微流控设备在生产聚己内酯（PCL）纳米颗粒尺寸均匀分布中的潜在应用。用不同的设计制造了五种微流体装置。研究了不同的操作和几何因素（例如流量比（FRR），总流量（TFR），混合通道宽度，混合通道长度以及入口通道的汇合角）对尺寸，多分散指数（PDI）的影响，以及PCL粒子的尺寸分布。此外，进行了研究以提高PCL纳米颗粒的生产通量。纳米粒子的平均尺寸被精确控制在40-370 nm范围内，PDI值为0.2-0.37。根据结果​​，^-1，通道宽度为200μm，通道长度为20 mm，汇合角为60 ^o。此外，具有较宽的通道宽度600μm的微流体装置，与其他宽度的PCL纳米颗粒相比，具有相似的尺寸和更低的PDI，可提​​供更高的生产率。