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Asymmetric Chlorination of 4-Substituted Pyrazolones Catalyzed by Chiral Copper Complexes
Synlett ( IF 1.7 ) Pub Date : 2020-03-31 , DOI: 10.1055/s-0039-1690879 Yi-Feng Wang , Xue-Yang Chen 1 , Zhen-Hui Jiang , Wan-Zhen Ju , Hao Yin , Suo-Suo Qi , Ming-Ming Chu
Synlett ( IF 1.7 ) Pub Date : 2020-03-31 , DOI: 10.1055/s-0039-1690879 Yi-Feng Wang , Xue-Yang Chen 1 , Zhen-Hui Jiang , Wan-Zhen Ju , Hao Yin , Suo-Suo Qi , Ming-Ming Chu
Affiliation
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A fast and highly enantioselective chlorination of 4-pyrazolones catalyzed by bis(oxazoline)–Cu(ClO4)2·6H2O complexes has been developed. Under the optimized conditions, a series of pyrazolones bearing stereogenic chlorine-attached carbon centers were obtained in moderate to high yields (up to 98%) and with enantioselectivities of up to 98% ee.
中文翻译：
手性铜配合物催化4-取代吡唑啉酮的不对称氯化
已经开发了一种由双（恶唑啉）-Cu(ClO4)2·6H2O 配合物催化的 4-吡唑啉酮的快速和高度对映选择性氯化。在优化条件下，以中高产率（高达98%）和对映选择性高达98%ee获得了一系列带有立体异构氯连接碳中心的吡唑啉酮。
更新日期：2020-03-31
中文翻译：
手性铜配合物催化4-取代吡唑啉酮的不对称氯化
已经开发了一种由双（恶唑啉）-Cu(ClO4)2·6H2O 配合物催化的 4-吡唑啉酮的快速和高度对映选择性氯化。在优化条件下，以中高产率（高达98%）和对映选择性高达98%ee获得了一系列带有立体异构氯连接碳中心的吡唑啉酮。
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