Wound Healing Properties of Histatin-5 and Identification of a Functional Domain Required for Histatin-5-Induced Cell Migration.,Molecular Therapy - Methods & Clinical Development

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Wound Healing Properties of Histatin-5 and Identification of a Functional Domain Required for Histatin-5-Induced Cell Migration.
Molecular Therapy - Methods & Clinical Development ( IF 4.6 ) Pub Date : 2020-03-31 , DOI: 10.1016/j.omtm.2020.03.027
Dhara Shah ₁ , Kyung-No Son ₁ , Sushma Kalmodia ₁ , Bao-Shiang Lee ₂ , Marwan Ali ₁ , Arun Balasubramaniam ₁ , Deepak Shukla _{1,

3} , Vinay Kumar Aakalu ₁

Affiliation

Histatin peptides are endogenous anti-microbial peptides that were originally discovered in the saliva. Aside from their broad anti-microbial properties, these peptides play an important role in multiple biological systems. Different members of this family are thought to have relative specializations, with histatin-5 originally being thought to have mostly anti-fungal properties, and histatin-1 having strong wound healing properties. In this report, we describe the robust wound healing properties of histatin-5 and elucidate a functional domain, which is necessary and sufficient for promoting wound healing. We demonstrate these findings in multiple different cell types in vitro and with a standardized murine corneal wound healing model. Discovery of this wound healing domain and description of this functional role of histatin-5 will support developing therapies.

中文翻译：

Histatin-5的伤口愈合特性和Histatin-5诱导的细胞迁移所需功能域的鉴定。

组蛋白肽是最初在唾液中发现的内源性抗微生物肽。除了具有广泛的抗微生物特性外，这些肽还在多种生物系统中发挥重要作用。该家族的不同成员被认为具有相对的专长，最初认为histatin-5主要具有抗真菌特性，而histatin-1具有很强的伤口愈合特性。在这份报告中，我们描述了histatin-5的强大伤口愈合特性，并阐明了促进伤口愈合所必需和足够的功能性结构域。我们在体外和具有标准化的鼠角膜伤口愈合模型的多种不同细胞类型中证明了这些发现。

更新日期：2020-03-31

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