Abstract Ultraviolet B (UVB) radiation from sunlight has been epidemiologically identified as the main risk factor for skin photodamage such as skin pigmentation and cancer. Kaolinite two-dimensional (2D) nanoclay with suitable size has been used to prevent acute and chronic effects of UVB through specular reflection. However, the large size of 2D nanoclay absorbs sunlight as heat, and the small size of 2D nanoclay blocks sunlight incompletely. The UVB-induced zebrafish embryo pigmentation and the guinea pig skin erythema reaction and skin-stimulating response of kaolinite 2D nanoclay are size-dependent. Guinea pig skin treated with Kaolinite0.5μm (0.5 μm of kaolinite) showed the slightest skin irritation, and the protective effect against UVB was similar to that of the commercial sunburn Winona. Research on the size-dependent blocking effect of kaolinite 2D nanoclay against UVB-induced skin photodamage provides a complete analysis of the different sizes of 2D nanoclay to achieve UVB blocking.

中文翻译：

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尺寸依赖性二维纳米粘土在体外和体内对抗紫外线 B 诱导的损伤

摘要 来自阳光的紫外线 B (UVB) 辐射已被流行病学确定为皮肤光损伤的主要危险因素，如皮肤色素沉着和癌症。尺寸合适的高岭石二维 (2D) 纳米粘土已被用于通过镜面反射防止 UVB 的急性和慢性影响。然而，大尺寸的二维纳米粘土以热量的形式吸收阳光，而小尺寸的二维纳米粘土不能完全阻挡阳光。UVB 诱导的斑马鱼胚胎色素沉着和豚鼠皮肤红斑反应和高岭石二维纳米粘土的皮肤刺激反应是尺寸依赖性的。用 Kaolinite0.5μm（0.5μm 高岭石）处理的豚鼠皮肤表现出最轻微的皮肤刺激，对 UVB 的保护作用与商业晒伤 Winona 相似。