It is widely recognized that after endocytosis, internalized cargo is delivered to endosomes that act as sorting stations. The limiting membrane of endosomes contain specialized subregions, or microdomains, that represent distinct functions of the endosome, including regions competing for cargo capture leading to degradation or recycling. Great progress has been made in defining the endosomal protein coats that sort cargo in these domains, including Retromer that recycles transmembrane cargo, and ESCRT (endosomal sorting complex required for transport) that degrades transmembrane cargo. In this review, we discuss recent work that is beginning to unravel how such coat complexes contribute to the creation and maintenance of endosomal microdomains. We highlight data that indicates that adjacent microdomains do not act independently but rather interact to cross-regulate. We posit that these interactions provide an agile means for the cell to adjust sorting in response to extracellular signals and intracellular metabolic cues.

中文翻译：

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内体微区：形成和功能。

人们普遍认为，内吞作用后，内化的货物被输送到充当分选站的内体。内体的限制膜包含专门的亚区域或微域，代表内体的不同功能，包括竞争货物捕获导致降解或回收的区域。在定义这些领域中对货物进行分类的内体蛋白外壳方面已经取得了巨大进展，包括回收跨膜货物的Retromer，以及降解跨膜货物的ESCRT（运输所需的内体分选复合物）。在这篇综述中，我们讨论了最近的工作，这些工作开始揭示这种外壳复合物如何有助于内体微域的产生和维持。我们重点介绍的数据表明，相邻的微域不是独立作用，而是相互作用以进行交叉调节。我们认为这些相互作用为细胞提供了一种灵活的手段来调整排序以响应细胞外信号和细胞内代谢线索。