Extracellular vesicles for tumor targeting delivery based on five features principle.,Journal of Controlled Release

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Extracellular vesicles for tumor targeting delivery based on five features principle.
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.jconrel.2020.03.039
Tuying Yong ₁ , Dongdong Wang ₁ , Xin Li ₁ , Yuchen Yan ₁ , Jun Hu ₁ , Lu Gan ₁ , Xiangliang Yang ₁

Affiliation

Extracellular vesicles (EVs) are membrane vesicles with size of nanometers to several micrometers, which are released by most eukaryotic and prokaryotic cells. Recently, EVs-based nanomedicines have achieved remarkable attentions. Five features need to be satisfied for EVs-based nanomedicine to achieve desirable anticancer activity after systemic administration, including long circulation, enhanced tumor accumulation, deep tumor penetration, efficient cellular internalization and drug release. In this review, we summarize recently reported EVs-based nanomedicines for efficient drug delivery based on our defined five features principle theory. Even though EVs-based nanomedicines are in infancy, it is expectable that they exhibit promising prospects for cancer treatment.

中文翻译：

基于五个特征原理的用于肿瘤靶向递送的细胞外囊泡。

细胞外囊泡（EVs）是大小为纳米到几微米的膜囊泡，大多数真核细胞和原核细胞都会释放它们。近来，基于电动汽车的纳米药物受到了极大的关注。全身给药后，基于电动汽车的纳米药物需要达到五个特征，才能达到理想的抗癌活性，包括长循环，增强肿瘤蓄积，肿瘤深层渗透，有效的细胞内化和药物释放。在这篇综述中，我们基于我们定义的五种特征原理，总结了最近报道的基于电动汽车的纳米药物，用于有效的药物输送。即使基于电动汽车的纳米药物尚处于婴儿期，也可以期望它们在癌症治疗方面显示出广阔的前景。

更新日期：2020-04-01

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