Free radical-releasing systems for targeting biofilms.,Journal of Controlled Release

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Free radical-releasing systems for targeting biofilms.
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.jconrel.2020.03.031
Victoria Fasiku Oluwaseun ₁ , Calvin A Omolo ₂ , Thirumala Govender ₁

Affiliation

The recent rise in antibiotic drug resistance and biofilm formation by microorganisms has driven scientists from different fields to develop newer strategies to target microorganisms responsible for infectious diseases. There is a growing interest in free radicals as therapeutic agents for antimicrobial applications. However, limitations such as short half-life has hindered their usage. Currently, several research groups are exploring various biomaterials that can prolong the half-life, increase storage duration and control the release of the therapeutic ranges of free radicals required for different applications, including biofilm eradication. This review paper initially provides a background to, and theoretical knowledge on, free radicals; and then proceeds to review studies that have employed various free radical-incorporated drug delivery systems as an approach to target biofilm formation and eradication. Some of the free radical releasing systems highlighted include polymers, nanoparticles and hydrogels, with a focus on biofilm eradication, where they impact significantly. The various challenges associated with their application are also discussed. Further, the review identifies future research and strategies that can potentiate the application of free radical-incorporated drug delivery systems for inhibiting biofilm formation and eradicating formed biofilms.

中文翻译：

靶向生物膜的自由基释放系统。

微生物对抗生素的耐药性和生物膜形成的最新发展推动了来自不同领域的科学家们开发新的策略，以靶向于引起传染病的微生物。自由基作为抗微生物应用的治疗剂的兴趣与日俱增。然而，诸如半衰期短的限制阻碍了它们的使用。当前，几个研究小组正在探索各种生物材料，这些材料可延长半衰期，增加储存时间并控制释放不同用途（包括消除生物膜）所需的治疗范围的自由基。本文首先提供了自由基的背景知识和理论知识；然后着手审查采用各种结合了自由基的药物递送系统作为靶向生物膜形成和根除方法的研究。突出显示的一些自由基释放系统包括聚合物，纳米颗粒和水凝胶，其重点是消除生物膜，在这些生物膜上会产生重大影响。还讨论了与它们的应用相关的各种挑战。此外，该综述确定了未来的研究和策略，这些研究和策略可以增强结合自由基的药物递送系统在抑制生物膜形成和消除形成的生物膜方面的应用。它们在哪里产生重大影响。还讨论了与它们的应用相关的各种挑战。此外，该综述确定了未来的研究和策略，这些研究和策略可以增强结合自由基的药物递送系统在抑制生物膜形成和消除形成的生物膜方面的应用。它们在哪里产生重大影响。还讨论了与它们的应用相关的各种挑战。此外，该综述确定了未来的研究和策略，这些研究和策略可以增强结合自由基的药物递送系统在抑制生物膜形成和消除形成的生物膜方面的应用。

更新日期：2020-04-01

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