Triphenyl phosphate modulated saturation of phospholipids: Induction of endoplasmic reticulum stress and inflammation.,Environmental Pollution

当前位置： X-MOL 学术 › Environ. Pollut. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Triphenyl phosphate modulated saturation of phospholipids: Induction of endoplasmic reticulum stress and inflammation.
Environmental Pollution ( IF 7.6 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.envpol.2020.114474
Wenxin Hu ₁ , Qiyue Kang ₁ , Chenhao Zhang ₁ , Haojia Ma ₁ , Chenke Xu ₁ , Yi Wan ₁ , Jianying Hu ₁

Affiliation

Although triphenyl phosphate (TPHP) has been reported to disrupt lipid metabolism, the effect of TPHP on lipid saturation remains unexplored. In this study, a lipidomic analysis demonstrated decreases in the levels of poly-unsaturated phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in RAW264.7 murine macrophage cells exposed to 10 μM TPHP. The expression of the gene encoding lysophosphatidylcholine acyltransferase 3 (Lpcat3) was significantly downregulated by 0.76 ± 0.03 and 0.70 ± 0.08-fold in 10 and 20 μM TPHP exposure groups, relative to the control group. This finding explains the observed decrease in lipid saturation. Correspondingly, exposure to 10 and 20 μM TPHP induced endoplasmic reticulum (ER) stress and inflammatory responses, which have been linked to metabolic dysfunction such as insulin resistance and hypertriglyceridemia. Therefore, TPHP may pose a risk to human health by promoting metabolic diseases.

中文翻译：

磷酸三苯酯调节磷脂的饱和度：诱导内质网应激和炎症。

尽管已报道磷酸三苯酯（TPHP）会破坏脂质的代谢，但尚未探讨TPHP对脂质饱和的影响。在这项研究中，脂质组学分析表明，暴露于10μMTPHP的RAW264.7鼠巨噬细胞中多不饱和磷脂酰胆碱（PC），磷脂酰乙醇胺（PE）和磷脂酰丝氨酸（PS）含量降低。相对于对照组，在10和20μMTPHP暴露组中，编码溶血磷脂酰胆碱酰基转移酶3（Lpcat3）的基因表达显着下调了0.76±0.03和0.70±0.08倍。这一发现解释了所观察到的脂质饱和度降低。相应地，暴露于10和20μMTPHP会引起内质网（ER）应激和炎症反应，与代谢功能异常有关，例如胰岛素抵抗和高甘油三酯血症。因此，TPHP可能通过促进代谢性疾病而对人类健康构成威胁。

更新日期：2020-04-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11