Background

There is paucity of information on clinical characteristics and outcome of patients with familial atrial fibrillation (AF). The present study was aimed to compare clinical profile and outcome of familial AF with those of non-familial AF.

Methods

Between February 2017 and February 2018, we enrolled 738 participants (60% men, median age, 51 years in familial AF vs. 61 years in non-familial AF) from Iranian Registry of AF. All patients were followed for 12 months. Clinical characteristics and main outcome measures for AF patients were obtained from patient's medical records.

Results

A positive history of AF in first-degree relative was reported in 15.3% of our AF population. Familial AF group were significantly younger than non-familial group (p = 0.001). Concomitant sinus node dysfunction and cardiomyopathies were more common in familial AF group (p = 0.02, p = 0.004, respectively). Patients with familial AF were also likely to receive cardiac devices and AF catheter ablation (all p < 0.05). However, all-cause mortality and thromboembolic events were similar (all p > 0.05).

Conclusions

Familial AF patients were more likely to have associated rhythm disorders and dilated cardiomyopathies. Cardiac interventions were also more common in familial patients. However, they did not differ significantly in their long-term outcome.

中文翻译：

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家族性和非家族性心房颤动的临床特征和结局。

背景

缺乏有关家族性房颤（AF）患者临床特征和预后的信息。本研究旨在比较家族性AF与非家族性AF的临床特征和结果。

方法

在2017年2月至2018年2月之间，我们从伊朗AF登记处招募了738名参与者（男性为60％，中位年龄，家族性AF为51岁，非家族性AF为61岁）。所有患者均随访12个月。AF患者的临床特征和主要结局指标来自患者的病历。

结果

据报道，在我们的AF人群中，有15.3％的一级亲属有AF阳性史。家族性AF组比非家族性AF组明显年轻（p  = 0.001）。家族性AF组并发窦房结功能障碍和心肌病更为常见（分别为p  = 0.02，p  = 0.004）。家族性AF患者也可能接受心脏设备和AF导管消融术（所有p  <0.05）。但是，全因死亡率和血栓栓塞事件相似（所有p  > 0.05）。

结论

家族性AF患者更有可能伴有节律紊乱和扩张型心肌病。在家族性患者中，心脏干预也更为普遍。但是，他们的长期结果没有显着差异。