Estimation of Plasmodium vivax biomass based on circulating biomarkers indicates the existence of a predominant biomass outside of the circulation that is not captured by peripheral parasitemia, in particular in patients with complicated outcomes. A series of recent studies have suggested that the hematopoietic niche of the bone marrow (BM) is a major reservoir for parasite replication and the development of transmission stages. However, significant knowledge gaps remain in our understanding of host-parasite interactions, pathophysiology, and the implications for treatment and diagnosis of such a reservoir. Here, we discuss the current status of this emerging research field in the context of P. vivax.

中文翻译：

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造血Ni中的间日疟原虫：隐患和危险。

根据循环生物标志物估算间日疟原虫的生物量表明，循环外存在着主要的生物量，外围的寄生虫病并没有捕获这种生物量，特别是在结果复杂的患者中。一系列最近的研究表明，骨髓的造血环境（BM）是寄生虫复制和传播阶段发展的主要来源。然而，在我们对宿主-寄生虫相互作用，病理生理以及对这种储层的治疗和诊断的意义的理解上，仍然存在重大的知识空白。在这里，我们讨论了间日疟原虫这一新兴研究领域的现状。