The protective effect of Lactobacillus plantarum CCFM436 (L. plantarum CCFM436) against acute Mn toxicity was studied in mice based on an evaluation of its administration as a therapy or as a prevention strategy. Viable and nonviable L. plantarum CCFM436 cells showed better Mn binding ability than the other 8 Lactobacillus strains. The levels of Mn in feces, liver, kidney, and brain suggested its potential for alleviating acute Mn toxicity in mice. With the administration of viable CCFM436, the content of malondialdehyde decreased, while glutathione, superoxide dismutase, and catalase activity increased in tissues, which were beneficial for reducing the hepatic, renal, and cerebral oxidative stress. The reduction of the levels of pro-inflammatory cytokines and amyloid beta and the increase of the expression of TJ proteins in brain tissue showed the protective effect against Mn toxicity. The study suggested that L. plantarum CCFM436 was effective against Mn toxicity and could be considered as a potential dietary therapeutic strategy against acute Mn toxicity.

基于其作为治疗或预防策略的评价，在小鼠中研究了植物乳杆菌CCFM436（植物乳杆菌CCFM436）对急性Mn毒性的保护作用。活的和不活的植物乳杆菌CCFM436细胞显示出比其他8种乳酸菌更好的Mn结合能力株。粪便，肝脏，肾脏和大脑中的锰含量表明其具有减轻小鼠急性锰毒性的潜力。通过施用可行的CCFM436，组织中的丙二醛含量降低，而谷胱甘肽，超氧化物歧化酶和过氧化氢酶活性增加，这有利于减轻肝，肾和脑的氧化应激。脑组织中促炎性细胞因子和淀粉样β的水平降低以及TJ蛋白表达的增加显示出对Mn毒性的保护作用。该研究表明植物乳杆菌CCFM436对锰毒性有效，并且可以被认为是对急性锰毒性的潜在饮食治疗策略。