Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver regeneration. We found that following partial hepatectomy, the senescence-associated genes p21, p16^Ink4a, and p19^Arf become dynamically expressed in different cell types when regenerative capacity decreases, but without a full senescent response. However, we show that treatment with a senescence-inhibiting drug improves regeneration, by disrupting aberrantly prolonged p21 expression. This work suggests that senescence may initially develop from heterogeneous cellular responses, and that senotherapeutic drugs might be useful in promoting organ regeneration.

中文翻译：

---

化疗药物ABT-737破坏了异常的p21表达，以恢复成年小鼠的肝脏再生。

年轻的哺乳动物在某些组织中具有有限的再生能力，这些能力在成熟后会丧失。我们调查了细胞衰老是否可能在肝再生过程中的这种损失中起作用。我们发现，在部分肝切除术后，与衰老相关的基因p21，p16 ^Ink4a和p19 ^Arf在再生能力降低时会在不同细胞类型中动态表达，但没有完整的衰老反应。但是，我们显示，通过抑制异常延长的p21表达，使用抑制衰老的药物可以改善再生。这项工作表明，衰老可能最初是由异种细胞反应发展而来的，而治疗性药物可能对促进器官再生有用。