The nanotechnology community can contribute significantly in the fight against COVID-19. Rapid point-of-care diagnostics. Persons infected with SARS-CoV-2 present with a wide range of symptoms similar to other respiratory infections (e.g., fever, cough, and shortness of breath) or may be silent carriers. Communal spread of COVID-19 is a major concern. The availability of a cost-effective, rapid point-of-care diagnostic test available to doctors in emergency rooms, clinics, and community hospitals is critical. These diagnostics enable frontline workers to triage patients simply and to prevent further spread of the virus. Surveillance and monitoring. Diagnostics are critical in determining the spread of an infection. Mass surveillance with rapid diagnostics helps public health officials monitor virus spread, proactively identify areas with increasing infections, anticipate surge capacity needs, and deploy needed resources to the appropriate areas. The success of such a system hinges on clear and transparent collaboration and communications between federal and state/principal public health laboratories, hospitals, government agencies, and communities. The World Health Organization and others have argued that widespread testing will be needed to stop this pandemic.(6) Therapeutics. Patients may need to be treated once individuals with COVID-19 are identified. These therapies block the replication of the virus in the host. Basic studies of the nano-bio interactions could be adapted to understand how SARS-CoV-2 infects their cells (e.g., SARS-CoV-2 is 60–140 nm and binds to angiotensin converting enzyme receptor 2, ACE2), which can lead to new therapeutic agents and design. Vaccine development. Vaccines are instrumental in preventing disease by boosting the immune system against a pathogen. One vaccine being evaluated is a messenger RNA (mRNA)–lipid nanoparticle vaccine based on the previous studies of SARS-CoV and the Middle East Respiratory Syndrome (MERS).(5) In the fight against COVID-19, research and technology development and deployment are our best weapons. Views expressed in this editorial are those of the author and not necessarily the views of the ACS. This article references 8 other publications.

中文翻译：

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COVID-19 纳米研究。

纳米技术界可以为抗击 COVID-19 做出重大贡献。快速护理点诊断。感染 SARS-CoV-2 的人会出现与其他呼吸道感染相似的多种症状（例如发烧、咳嗽和呼吸急促），或者可能是隐性携带者。COVID-19 的社区传播是一个主要问题。为急诊室、诊所和社区医院的医生提供经济高效、快速的护理点诊断测试至关重要。这些诊断使一线工作人员能够简单地对患者进行分类，并防止病毒进一步传播。监视和监视。诊断对于确定感染的传播至关重要。大规模监测和快速诊断有助于公共卫生官员监测病毒传播，主动识别感染增加的地区，预测激增的容量需求，并将所需资源部署到适当的地区。这一系统的成功取决于联邦和州/主要公共卫生实验室、医院、政府机构和社区之间清晰、透明的合作和沟通。世界卫生组织和其他组织认为，需要进行广泛的测试来阻止这种流行病。(6)治疗。一旦发现患有 COVID-19 的患者，患者可能需要接受治疗。这些疗法阻止病毒在宿主体内复制。纳米生物相互作用的基础研究可以用于了解 SARS-CoV-2 如何感染细胞（例如，SARS-CoV-2 为 60-140 nm，并与血管紧张素转换酶受体 2，ACE2 结合），这可以导致新的治疗剂和设计。疫苗开发。疫苗通过增强针对病原体的免疫系统来预防疾病。正在评估的一种疫苗是基于先前对 SARS-CoV 和中东呼吸综合征 (MERS) 的研究的信使 RNA (mRNA)-脂质纳米颗粒疫苗。(5)在抗击 COVID-19 的斗争中，研究、技术开发和部署是我们最好的武器。本社论中表达的观点仅代表作者的观点，并不一定代表 ACS 的观点。本文参考了其他 8 篇出版物。