当前位置: X-MOL 学术Cancer Discov. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Letting the GENIE Out of Its Bottle: Examining the Potential of Real-World Clinicogenomic Data
Cancer Discovery ( IF 29.7 ) Pub Date : 2020-04-01 , DOI: 10.1158/2159-8290.cd-20-0039
Emily Castellanos 1 , Shrujal S. Baxi 1
Affiliation  

Summary: In this issue, Smyth and colleagues investigate the natural history of AKT1 -mutant metastatic breast cancer using the AACR Project GENIE, a novel research platform comprised of real-world, clinicogenomic data. A rare subset of tumors, AKT1 -mutant breast cancers demonstrated similar clinical and demographic characteristics and overall survival as AKT1 –wild-type tumors, but a longer duration of therapy on mTOR inhibitors. See related article by Smyth et al., [p. 526][1] . [1]: /lookup/volpage/10/526?iss=4

中文翻译:

让GENIE脱颖而出:检查现实世界中临床基因组数据的潜力

简介:在本期中,Smyth及其同事使用AACR Project GENIE研究了AKT1突变型转移性乳腺癌的自然病史,这是一个由现实世界中临床基因组学数据组成的新颖研究平台。AKT1突变型乳腺癌是一种罕见的肿瘤子集,与AKT1野生型肿瘤相比,具有相似的临床和人口统计学特征以及总体生存率,但是mTOR抑制剂的治疗时间更长。参见Smyth等人的相关文章,[p。526] [1]。[1]:/ lookup / volpage / 10/526?iss = 4
更新日期:2020-04-01
down
wechat
bug