Summary: In this issue, Smyth and colleagues investigate the natural history of AKT1 -mutant metastatic breast cancer using the AACR Project GENIE, a novel research platform comprised of real-world, clinicogenomic data. A rare subset of tumors, AKT1 -mutant breast cancers demonstrated similar clinical and demographic characteristics and overall survival as AKT1 –wild-type tumors, but a longer duration of therapy on mTOR inhibitors. See related article by Smyth et al., [p. 526][1] . [1]: /lookup/volpage/10/526?iss=4

中文翻译：

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让GENIE脱颖而出：检查现实世界中临床基因组数据的潜力

简介：在本期中，Smyth及其同事使用AACR Project GENIE研究了AKT1突变型转移性乳腺癌的自然病史，这是一个由现实世界中临床基因组学数据组成的新颖研究平台。AKT1突变型乳腺癌是一种罕见的肿瘤子集，与AKT1野生型肿瘤相比，具有相似的临床和人口统计学特征以及总体生存率，但是mTOR抑制剂的治疗时间更长。参见Smyth等人的相关文章，[p。526] [1]。[1]：/ lookup / volpage / 10/526？iss = 4