当前位置：
X-MOL 学术
›
Evol. Appl.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cancer therapeutics inspired by defense mechanisms in the animal kingdom
Evolutionary Applications ( IF 4.1 ) Pub Date : 2020-05-04 , DOI: 10.1111/eva.12963 Kathleen Noble 1 , Aarushi Rohaj 1 , Lisa M. Abegglen 1, 2 , Joshua D. Schiffman 1, 2, 3
Evolutionary Applications ( IF 4.1 ) Pub Date : 2020-05-04 , DOI: 10.1111/eva.12963 Kathleen Noble 1 , Aarushi Rohaj 1 , Lisa M. Abegglen 1, 2 , Joshua D. Schiffman 1, 2, 3
Affiliation
Many animals have evolved toxins to defend themselves from predators and hunt prey. These toxins have been honed over millions of years by the unique selective pressures on each organism leading to a vast array of potent bioactive compounds, many of which have therapeutic potential. Animal extracts have been used for medicinal purposes for thousands of years, and in the past 50 years, hundreds of animal‐derived compounds have been investigated for anticancer activity with a notable number showing significant potential. This review covers some of the most promising animal‐derived cancer therapeutic agents currently in use or under investigation. Potential therapeutic agents derived from insects, arachnids, amphibians, and marine organism are included. Four compounds are highlighted in this review: bee venom from honeybees (Apis mellifera), chlorotoxin from the Israeli deathstalker scorpion (Leiurus quinquestriatus), Huachansu from Chinese Bufo toads (Bufo bufo gargarizans and B. melanotictus), and trabectedin from the marine tunicate Ecteinascidia turbinate. For each compound, the history of their discovery, their mechanism of action, and their clinical development are discussed.
更新日期：2020-05-04
京公网安备 11010802027423号