Despite the availability of guidelines for the management of chronic myeloid leukaemia (CML), various issues may prevent their successful implementation. The TARGET survey examined real‐world management of CML patients compared with international recommendations. This online survey was completed in 2017. Results were discussed by a Steering Committee (SC) of eight international haematologists, challenges were identified and practical solutions developed. Of the 1008 haematologists invited (33 countries), 614 completed the survey. Gaps regarding treatment efficacy and molecular monitoring were identified. Half of the physicians did not perform three‐monthly testing of during the initial 12 months of treatment, citing cost as the major barrier, although they know it should be done. Treatment‐free remission was not considered a primary treatment goal or as a priority factor influencing treatment decisions. European Leukemia Net guidelines interpretation was generally acceptable, but awareness regarding management of persistent adverse events was poor. Practical solutions proposed by the SC were mostly focused on enhancing physician education and awareness, or encouraging hospitals to work with the government, in order to improve the quality of BCR‐ABL testing. Gaps in current CML management were identified compared with international recommendations, which the proposed practical solutions would help to address.

中文翻译：

---

目标：对33个国家/地区的慢性粒细胞白血病进行现实管理的调查

尽管有管理慢性粒细胞白血病（CML）的指南，但各种问题仍可能阻止其成功实施。TARGET调查检查了CML患者在现实世界中的治疗情况，并与国际建议进行了比较。该在线调查于2017年完成。由八名国际血液学家指导委员会（SC）讨论了结果，确定了挑战并提出了切实可行的解决方案。在受邀的1008名血液学家（33个国家）中，有614位完成了调查。确定了有关治疗功效和分子监测的空白。一半的医生在治疗的最初12个月中没有进行为期3个月的测试，尽管他们认为应该这样做，但认为费用是主要障碍。无治疗缓解不被视为主要治疗目标，也不被视为影响治疗决策的优先因素。欧洲白血病网指南的解释通常是可以接受的，但是对持续不良事件的管理意识却很差。标准委提出的实用解决方案主要集中在提高医师的教育水平和认识，或鼓励医院与政府合作，以提高BCR-ABL测试的质量。确定了当前CML管理中的差距与国际建议，建议的实际解决方案将有助于解决这些建议。标准委提出的实用解决方案主要集中在提高医师的教育水平和认识，或鼓励医院与政府合作，以提高BCR-ABL测试的质量。确定了当前CML管理中的差距与国际建议，建议的实际解决方案将有助于解决这些建议。标准委提出的实用解决方案主要集中在提高医师的教育水平和认识，或鼓励医院与政府合作，以提高BCR-ABL测试的质量。确定了当前CML管理中的差距与国际建议，建议的实际解决方案将有助于解决这些建议。