A retrospect on antimicrobial potential of thiazole scaffold,Journal of Heterocyclic Chemistry

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A retrospect on antimicrobial potential of thiazole scaffold
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-03-30 , DOI: 10.1002/jhet.3970
Isha Mishra _{1,

2} , Raghav Mishra ₂ , Somdutt Mujwar ₂ , Phool Chandra ₁ , Neetu Sachan ₁

Affiliation

Due to its appreciable diversity in biological actions, thiazole and its substituted components, a significant class of heterocyclic compounds has developed as an influential scaffold in the field of chemical sciences. The variability of thiazole core has been expressed through the effective instigation of its anticancer (Dasatinib, Tiazofurin), antiretroviral (Ritonavir, Brecanavir), antimicrobial (Sulfathiazole, Ravuconazole) and anti‐inflammatory (Fenclozic acid, Meloxicam) derivatives. This reasonable diversity in the physiological reaction pattern led many scientists to refine and develop new structural alternatives with much more efficient pharmacological action. This review is crucial for previous studies and projects to survey the antimicrobial activity of thiazole and thiazole related compounds to the mid of 2019.

中文翻译：

噻唑支架抗菌潜力的回顾

由于其在生物作用，噻唑及其取代的成分方面的显着多样性，已开发出一大类杂环化合物作为化学科学领域的重要支架。噻唑核心的可变性已通过有效地激发其抗癌药（达沙替尼，替硝林），抗逆转录病毒药（Ritonavir，布雷卡那韦），抗微生物药（磺胺噻唑，拉伏康唑）和抗炎药（苯氯酸，美洛昔康）来表达。生理反应模式的这种合理多样性导致许多科学家改进和开发具有更有效药理作用的新结构替代物。这项审查对于之前的研究和调查至2019年中期噻唑和噻唑相关化合物的抗菌活性至关重要。

更新日期：2020-03-30

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