Inhalation of odors can affect physiological parameter and change gene expression-related specific function. 2,5-Dimethyl-4-hydroxy-3(2H)-furanone (DMHF) is one of the major odor compounds generated by the Maillard reaction. We previously reported that the inhalation of DMHF decreased systolic blood pressure via the autonomic nervous system in rats. The autonomic nervous system is also closely related to appetite regulation. The present study investigated the effects of DMHF on dietary intake and gene expression. The inhalation of DMHF increased the dietary intake of rats during the feeding period. However, body weight did not change after 6 weeks feeding. A DNA microarray analysis showed that DMHF altered gene expression associated with feeding behavior and neurotransmission in the rat brain. DMHF inhalation promotes appetite and changes gene expression in rats. Furthermore, phenotypic changes may regulate neurotransmission and appetite at the mRNA level in addition to controlling the autonomic nervous system. PRACTICAL APPLICATION: DMHF is an important flavor component in the food industry. In this study, we first observed that the inhalation of DMHF promotes appetite. This finding is directly connected with the industrial application.

中文翻译：

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DMHF（2,5-二甲基-4-羟基-3（2H）-呋喃酮）是一种由美拉德反应产生的挥发性食物成分，通过吸入促进食欲并改变大鼠大脑中的基因表达

吸入气味会影响生理参数并改变与基因表达相关的特定功能。2,5-二甲基-4-羟基-3(2H)-呋喃酮 (DMHF) 是美拉德反应产生的主要气味化合物之一。我们之前报道过吸入 DMHF 通过大鼠自主神经系统降低收缩压。自主神经系统也与食欲调节密切相关。本研究调查了 DMHF 对饮食摄入和基因表达的影响。DMHF 的吸入增加了大鼠在喂食期间的膳食摄入量。然而，喂食6周后体重没有变化。DNA 微阵列分析表明，DMHF 改变了与大鼠大脑中的进食行为和神经传递相关的基因表达。DMHF 吸入促进食欲并改变大鼠的基因表达。此外，除了控制自主神经系统外，表型变化还可能在 mRNA 水平上调节神经传递和食欲。实际应用：DMHF 是食品工业中重要的风味成分。在这项研究中，我们首先观察到吸入 DMHF 会促进食欲。这一发现与工业应用直接相关。