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Scalable Electrochemical Transition‐Metal‐Free Dehydrogenative Cross‐Coupling Amination Enabled Alkaloid Clausines Synthesis
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-03-30 , DOI: 10.1002/adsc.202000228
Pan Zhang 1 , Baoying Li 1 , Liwei Niu 1 , Ling Wang 1 , Guofeng Zhang 1 , Xiaofei Jia 2 , Guoying Zhang 2 , Siyuan Liu 1 , Li Ma 1 , Wei Gao 1 , Dawei Qin 1 , Jianbin Chen 1
Affiliation  

Reported herein is an environmentally benign electrochemical C−H bond dehydrogenative amination protocol for the construction of privileged carbazole moiety with broad generality. Preliminary mechanistic investigations implied a radical reaction pathway. Compared with traditional ionic routes, the scalable transition‐metal and exogenous‐oxidant free strategy highlighted the green and sustainable nature of this method.

中文翻译:

可扩展的电化学无金属脱氢交叉偶联胺化生物碱黄嘌呤合成

本文报道的是一种环境友好的电化学CH键脱氢胺化方案,用于广泛地构建特权咔唑部分。初步的机理研究暗示了自由基反应途径。与传统的离子途径相比,可扩展的无过渡金属和无外源氧化剂的策略突出了这种方法的绿色和可持续性。
更新日期:2020-03-30
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