The ‘middle child’ of heart failure (HF) [patients with left ventricular ejection fraction (EF) in the 40–50% range] was christened HF with mid-range EF in 2014,¹ in recognition of the large gap in treatment evidence in this neglected subgroup of HF, with prior clinical trial evidence limited to those patients with EF of 40% or lower, and recent attention being showered upon those with EF of 50% or greater. While the EF 40–50% group was recognized as a ‘grey area’ in prior European Society of Cardiology Heart Failure Guidelines,² the name ‘heart failure with mid-range EF’ and acronym ‘HFmrEF’ was adopted in the 2016 guidelines,³ with the intention of bringing attention to this group of patients and addressing the evidence gap. The adoption of this nomenclature has inspired hundreds of publications which show that HFmrEF constitutes almost a fifth of the HF population, with patient demographics intermediate between those with lower and higher EFs, high frequency of coronary artery disease, and better prognosis than those with lower EF.⁴

中文翻译：

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是时候重命名心力衰竭的中产儿：射血分数轻度降低的心力衰竭。

心脏衰竭（HF）患者在40-50％的范围内左室射血分数（EF）的“中间的孩子”被命名为具有中档EF HF在2014年，¹治疗的证据，以表彰差距很大在这一被忽视的HF亚组中，先前的临床试验证据仅限于EF小于或等于40％的患者，最近注意力集中在EF大于或等于50％的患者身上。虽然EF 40-50％组被认定为前欧洲心脏病学会心力衰竭指南的，一个“灰色地带” ²名“心脏衰竭中档EF”和缩写“HFmrEF”在2016年的准则获得通过，³目的是引起对这组患者的关注并弥补证据不足。采用这种命名方式激发了数百篇出版物，这些出版物表明HFmrEF几乎占HF人群的五分之一，患者人口统计学特征介于EF较低和较高，冠心病高发和预后比EF较低的人群之间。 。⁴