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Ileocolic Intussusception as the Presenting Symptom of Primary Enteric Varicella-Zoster Virus Infection in a 7-Month-Old Infant.
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-03-31 , DOI: 10.1093/infdis/jiaa148
Jonathan D Windster 1 , Werner J D Ouwendijk 2 , Cornelius E J Sloots 1 , Georges M G M Verjans 2 , Robert M Verdijk 3
Affiliation  

Ileocolic intussusception is the invagination of ileum into the colon. In a subset of patients, the disease is caused by mesenteric lymphadenopathy in response to (viral) infection. We present a case of an ileocolic intussusception necessitating surgery in a 7-month old immunocompetent infant with concurrent primary wild-type varicella-zoster virus (VZV) infection, who developed chickenpox rash two days post-surgery. Detailed in situ analyses of resected intestine for specific cell type markers and VZV RNA demonstrated VZV-infected lymphocytes and neurons in the gut wall and in ganglion cells of the myenteric plexus.

中文翻译:

回肠肠套叠为7个月大婴儿原发性肠水痘-带状疱疹病毒感染的表现症状。

回肠肠套叠是回肠向结肠的内陷。在部分患者中,该疾病是由对(病毒)感染作出反应的肠系膜淋巴结病引起的。我们提出了一例回盲性肠套叠的病例,该病例需要在一个有免疫功能的7个月大婴儿中并发原发性野生型水痘-带状疱疹病毒(VZV)感染,在手术后两天出现水痘皮疹。对于特定细胞类型标记物和VZV RNA,对切除的肠进行详细的原位分析表明,肠壁和神经丛神经节细胞中VZV感染的淋巴细胞和神经元。
更新日期:2020-03-31
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