Abstract—

The purpose of the study was to identify patterns of changes in the levels of antibodies (ABs) against nervous tissue regulatory proteins during the post-contact period in patients with varying degrees of neurointoxication from metallic mercury vapor. We studied dependent samples collected in a 5 year period from men with first, second or third degree chronic mercury intoxication (CMI). By repeated study, an increase in antibodies against DNA and MAG proteins was found in individuals with early manifestations of mercury neurointoxication (stage I). ABs against NF-200, GFAP, S-100, myelin basic protein (MBP), voltage-dependent Ca-channels (VDCC), β2-GP, Glu-R, DA-R, GABA-R, Ser-R, and Ch-R did not change in dynamics and remained elevated relative to the control values, which reflects changes in the nervous and immune systems and involvement of these proteins in regulatory processes. In patients with stage II–III CMI, during the post-contact period an increase in ABs against the NF-200 protein and decreases in ABs against S-100, MAG, and GFAP proteins were revealed, which may indicate their importance in the pathological process after the cessation of contact with the toxicant. In total, the data suggest that the most informative biomarkers of the severity of CMI are ABs against proteins S-100, GFAP, and MAG.

中文翻译：

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接触后慢性汞中毒患者抗神经组织蛋白抗体的变化

摘要—

这项研究的目的是确定患有金属汞蒸气引起的神经中毒程度不同的患者，在接触后期间针对神经组织调节蛋白的抗体（ABs）水平变化的模式。我们研究了在5年内从一级，二级或三级慢性汞中毒（CMI）的男性中收集的相关样本。通过反复研究，发现具有汞神经中毒早期表现的个体（I期）的抗DNA和MAG蛋白抗体增加。抗NF-200，GFAP，S-100，髓磷脂碱性蛋白（MBP），电压依赖性Ca通道（VDCC），β2-GP，Glu-R，DA-R，GABA-R，Ser-R和Ch-R的动力学没有变化，相对于对照值仍保持升高，这反映了神经和免疫系统的变化以及这些蛋白质参与调节过程。在患有II–III期CMI的患者中，在接触后期间，发现NF-200蛋白的ABs升高，而S-100，MAG和GFAP蛋白的ABs降低，这可能表明它们在病理学中的重要性接触毒物后停止处理。总体而言，数据表明，CMI严重程度最有信息的生物标志物是针对蛋白质S-100，GFAP和MAG的AB。这可能表明它们在停止与有毒物质接触后在病理过程中的重要性。总体而言，数据表明，CMI严重程度最有信息的生物标志物是针对蛋白质S-100，GFAP和MAG的AB。这可能表明它们在停止与有毒物质接触后在病理过程中的重要性。总体而言，数据表明，CMI严重程度最有信息的生物标志物是针对蛋白质S-100，GFAP和MAG的AB。