Abstract

Monosodium glutamate (MSG) is widely used as food additive and flavor enhancer; however, consumption of high dose of MSG provokes oxidative stress in many organs and its safety and side effects on the body are still controversial. Therefore, it is crucial to investigate the long-lasting effects of MSG on cardiac muscle functions and structure. Forty male Wister albino rats were assigned into 3 groups. Control group was injected intraperitoneally with physiological saline for 7 days. Second group was injected intraperitoneally with MSG at a dose of 4 mg/g b.w/day for 7 consecutive days and then kept without any treatment till 45th day of the experiment. Third group was injected intraperitoneally with MSG at a dose of 6 mg/g b.w/day for 7 consecutive days and then kept without any treatment till 45th day of the experiment. Monosodium glutamate significantly reduced body weight, force of cardiac muscle contractility, serum level of high-density lipoprotein, and superoxide dismutase activity in cardiac muscle, while it significantly elevated heart rate, serum levels of total cholesterol, low-density lipoprotein, triacylglycerides, atherogenic index and troponin T, activities of serum lactate dehydrogenase and creatine kinase-MB, malondialdehyde concentration, and P53 protein expression in cardiac muscle. In addition, it induced myocardial degeneration, cellular infiltration, deposition of collagen in cardiac muscle, and periodic acid–Schiff staining reaction. This study indicated that MSG exerted long-lasting functional and structural alterations in the heart of male albino rats through induction of oxidative stress, atherogenesis, and apoptosis.

中文翻译：

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谷氨酸钠通过氧化应激，纤维化和大鼠P53凋亡蛋白的表达诱导心脏毒性。

摘要

味精（MSG）被广泛用作食品添加剂和增味剂；但是，高剂量的味精的摄入会在许多器官中引起氧化应激，其安全性和对人体的副作用仍存在争议。因此，研究味精对心肌功能和结构的长期影响至关重要。将40只雄性Wister白化病大鼠分为3组。对照组腹腔注射生理盐水7天。第二组连续7天腹腔注射味精，剂量为4 mg / g bw /天，然后连续第45天不进行任何治疗。第三组连续7天以6 mg / g bw /天的剂量腹膜内注射味精，然后在实验第45天之前不进行任何治疗。谷氨酸钠可显着降低体重，心肌收缩力，血清高密度脂蛋白水平和心肌超氧化物歧化酶活性，同时可显着提高心率，血清总胆固醇，低密度脂蛋白，甘油三酸酯，动脉粥样硬化指标和肌钙蛋白T，血清乳酸脱氢酶和肌酸激酶-MB活性，丙二醛浓度和心肌中P53蛋白的表达。此外，它还引起心肌变性，细胞浸润，胶原蛋白在心肌中的沉积以及高碘酸-席夫氏染色反应。这项研究表明，味精通过诱导氧化应激，动脉粥样硬化和细胞凋亡在雄性白化病大鼠的心脏中发挥了持久的功能和结构改变。