Abstract

Aluminum chloride (AlCl₃) has different industrial applications including manufacturing paint and water treatment. The present study was designed to evaluate the alleviating effect of geraniol against AlCl₃-induced hepatopancreatic toxicity. To this end, forty male Wistar rats were divided into control (0.9% NaCl, IP), geraniol (100 mg/kg orally), AlCl₃ (70 mg/kg, IP), and AlCl₃ (70 mg/kg, IP) plus geraniol (100 mg/kg orally) groups and then were treated daily for 28 days. Based on the results, serum cholesterol, triglyceride, as well as liver and pancreas enzymes increased significantly (P < 0.05) while the level of insulin significantly decreased in AlCl₃-treated rats compared to the control group (P < 0.05). The presence of geraniol relieved the toxic effects of AlCl₃ as well. On the other hand, the level of malondialdehyde (MDA) increased in the AlCl₃-treated group while the activities of glutathione peroxidase and the total antioxidant activity demonstrated a reduction. However, the MDA level decreased while the antioxidant enzymes increased in co-treated with geraniol group. Histopathological examination revealed that simultaneous treatment with geraniol in AlCl₃ intoxicated rats ameliorate the liver lesions such as necrosis, inflammatory cell infiltration, vacuolar degeneration, along with hyperemia and the cell density of the Langerhans islands. Finally, the results indicated that geraniol attenuated the side effect of AlCl₃-induced hepatopancreatic toxicity.

中文翻译：

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香叶醇可减轻雄性Wistar大鼠在氯化铝-肝胰腺毒性过程中的氧化应激，生物蓄积，血清学和组织病理学变化。

摘要

氯化铝（AlCl ₃）具有不同的工业应用，包括制造油漆和水处理。本研究旨在评估香叶醇对AlCl ₃诱导的肝胰腺毒性的缓解作用。为此，将四十只雄性Wistar大鼠分为对照组（0.9％NaCl，IP），香叶醇（100 mg / kg口服），AlCl ₃（70 mg / kg，IP）和AlCl ₃（70 mg / kg，IP） ）加香叶醇（100 mg / kg口服）组，然后每天治疗28天。根据结果​​， AlCl _3中的血清胆固醇，甘油三酸酯以及肝和胰腺酶显着增加（P <0.05），而胰岛素水平显着降低治疗的大鼠与对照组相比（P  <0.05）。香叶醇的存在也减轻了AlCl ₃的毒性作用。另一方面，在AlCl ₃处理组中，丙二醛（MDA）水平升高，而谷胱甘肽过氧化物酶活性和总抗氧化剂活性降低。然而，香叶醇组共同处理时MDA水平下降，而抗氧化酶增加。组织病理学检查显示，在AlCl ₃中同时使用香叶醇陶醉的大鼠改善肝脏损伤，例如坏死，炎性细胞浸润，液泡变性，充血和朗格汉斯群岛的细胞密度。最后，结果表明，香叶醇减轻了AlCl ₃诱导的肝胰腺毒性的副作用。