A new diarylheptanoid glycoside, acutissioside A (4), along with five known diarylheptanoids (1–3, 5, 6) was isolated from the twigs of Quercus acutissima Carruth. The structure of the new compound was determined via spectral analysis, including NMR spectra (1H and 13C NMR, 1H–1H COSY, HSQC, HMBC) and HR-ESI-MS, acid hydrolysis, and specific optical rotation data. The neuroprotective effect of all the diarylheptanoid compounds (1–6) was evaluated. Compound 1 exhibited NGF secretion to 154.60 ± 2.87%, which was stronger than that of the positive control 6-shogaol (140.45 ± 2.18%).

中文翻译：

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一种新的二芳基庚烷类化合物及其神经保护活性

从 Quercus acutissima Carruth 的枝条中分离出了一种新的二芳基庚烷苷 A (4) 以及五种已知的二芳基庚烷类化合物 (1–3, 5, 6)。新化合物的结构通过光谱分析确定，包括 NMR 光谱（1H 和 13C NMR、1H-1H COSY、HSQC、HMBC）和 HR-ESI-MS、酸水解和比旋光度数据。评估了所有二芳基庚烷类化合物 (1-6) 的神经保护作用。化合物 1 的 NGF 分泌达到 154.60 ± 2.87%，强于阳性对照 6-shogaol (140.45 ± 2.18%)。