How to pack materials into well-defined volumes efficiently has been a longstanding question of interest to physicists, material scientists, and mathematicians as these materials have broad applications ranging from shipping goods in commerce to seeds in agriculture and to spheroids in tissue engineering. How many marbles or gumball candies can you pack into a jar? Although these seem to be idle questions they have been studied for centuries and have recently become of greater interest with their broadening applications in science and medicine. Here, we study a similar problem where we try to pack cells into a spherical porous buckyball structure. The experimental limitations are short of the theoretical maximum packing density due to the microscale of the structures that the cells are being packed into. We show that we can pack more cells into a confined micro-structure (buckyball cage) by employing acoustofluidic activation and their hydrodynamic effect at the bottom of a liqu...

中文翻译：

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通过声流体激活增强布基球中的细胞堆积

如何有效地将材料包装成确定的体积一直是物理学家，材料科学家和数学家关注的一个长期问题，因为这些材料具有广泛的应用范围，从商业运输货物到农业种子到组织工程中的椭球。您可以将几个大理石或口香糖装进一个罐子？尽管这些似乎是闲着的问题，但它们已经研究了多个世纪，并且随着它们在科学和医学领域的广泛应用，最近引起了更大的兴趣。在这里，我们研究了一个类似的问题，即我们试图将细胞包装成球形多孔布基球结构。由于细胞要装入其中的结构的微观尺度，实验上的限制还没有达到理论上的最大堆积密度。