Protein flexibility and disorder is emerging as a crucial modulator of chromatin structure. Histone tail disorder enables transient binding of different molecules to the nucleosomes, thereby promoting heterogeneous and dynamic internucleosome interactions and making possible recruitment of a wide-range of regulatory and remodeling proteins. On the basis of extensive multiscale...

中文翻译：

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蛋白质紊乱和核小体不对称引起的染色质层次环的出现[生物物理学和计算生物学]

蛋白质的柔韧性和无序性正在成为染色质结构的关键调节剂。组蛋白尾部疾病使不同分子与核小体的瞬时结合成为可能，从而促进异质和动态核小体间的相互作用，并可能募集各种调节和重塑蛋白。在广泛的多尺度基础上...