Ral (Ras-like) GTPases are directly activated by oncogenic Ras GTPases. Mutant K-Ras (G12C) has enabled the development of covalent K-Ras inhibitors currently in clinical trials. However, Ral, and the overwhelming majority of mutant oncogenic K-Ras, are devoid of a druggable pocket and lack an accessible cysteine for the development of...

中文翻译：

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酪氨酸上的小分子共价键形成会形成结合位点，并抑制Ral GTPases的激活[生物化学]

Ral（类Ras）GTPases由致癌性Ras GTPases直接激活。突变K-Ras（G12C）使目前临床试验中的共价K-Ras抑制剂得以开发。但是，Ral和绝大多数的致癌突变K-Ras缺乏可药用的口袋，并且缺乏可开发的半胱氨酸。