The recognition of cis-regulatory RNA motifs in human transcripts by RNA binding proteins (RBPs) is essential for gene regulation. The molecular features that determine RBP specificity are often poorly understood. Here, we combined NMR structural biology with high-throughput iCLIP approaches to identify a regulatory mechanism for U2AF2 RNA recognition. We...

中文翻译：

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一种自抑制性分子内相互作用，可通过必需的剪接因子U2AF2证明RNA的识别[生物化学]

RNA结合蛋白（RBP）识别人类转录物中顺式调节RNA的基序对于基因调节至关重要。经常难以确定决定RBP特异性的分子特征。在这里，我们结合了NMR结构生物学和高通量iCLIP方法来确定U2AF2 RNA识别的调控机制。我们...