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Structural basis for DEAH-helicase activation by G-patch proteins [Biochemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-03-31
Michael K. Studer, Lazar Ivanović, Marco E. Weber, Sabrina Marti, Stefanie Jonas

RNA helicases of the DEAH/RHA family are involved in many essential cellular processes, such as splicing or ribosome biogenesis, where they remodel large RNA–protein complexes to facilitate transitions to the next intermediate. DEAH helicases couple adenosine triphosphate (ATP) hydrolysis to conformational changes of their catalytic core. This movement results in...

中文翻译:

G-斑驳蛋白激活DEAH-解旋酶的结构基础[生物化学]

DEAH / RHA家族的RNA解旋酶参与许多必不可少的细胞过程,例如剪接或核糖体生物发生,在那里它们重塑大型RNA-蛋白复合物以促进向下一中间体的过渡。DEAH解旋酶将三磷酸腺苷(ATP)水解耦合到其催化核心的构象变化。这一运动导致...
更新日期:2020-03-31
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