Prokaryotes and viruses have fought a long battle against each other. Prokaryotes use CRISPR–Cas-mediated adaptive immunity, while conversely, viruses evolve multiple anti-CRISPR (Acr) proteins to defeat these CRISPR–Cas systems. The type I-F CRISPR–Cas system in Pseudomonas aeruginosa requires the crRNA-guided surveillance complex (Csy complex) to recognize the invading DNA. Although...

中文翻译：

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通过cryo-EM揭示AcrF9，AcrF8和AcrF6对IF CRISPR-Cas复合物的抑制机制[生物物理学和计算生物学]

原核生物和病毒之间进行了长期的战斗。原核生物利用CRISPR–Cas介导的适应性免疫，相反，病毒进化出多种抗CRISPR（Acr）蛋白来击败这些CRISPR–Cas系统。铜绿假单胞菌中的IF CRISPR–Cas系统需要crRNA指导的监视复合体（Csy复合体）来识别入侵的DNA。虽然...