Interleukin-2 (IL-2) is a small α-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity heterotrimeric receptor complex (IL-2Rα/IL-2Rβ/γc). IL-2 has been shown to have therapeutic efficacy for immune diseases by preferentially expanding distinct T cell compartments, and several regulatory T cell (Treg)-biasing anti–IL-2 antibodies have been...

中文翻译：

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白介素2的可药性受螺旋帽开关控制的整体构象转变的调控[生物物理学和计算生物学]

白细胞介素2（IL-2）是一种小的α螺旋细胞因子，通过募集到高亲和力的异源三聚体受体复合物（IL-2Rα/IL-2Rβ/γc）来调节免疫细胞的稳态。通过优先扩大不同的T细胞区室，IL-2已显示出对免疫疾病的治疗功效，并且已经有几种偏向T细胞（Treg）的抗IL-2抗体...