Spatial cellular organization is fundamental for embryogenesis. Remarkably, coculturing embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) recapitulates this process, forming embryo-like structures. However, mechanisms driving ESC–TSC interaction remain elusive. We describe specialized ESC-generated cytonemes that react to TSC-secreted Wnts. Cytoneme formation and length are controlled by actin, intracellular...

中文翻译：

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专门的细胞因子诱导干细胞的自组织[细胞生物学]

空间细胞组织是胚胎发生的基础。值得注意的是，将胚胎干细胞（ESC）和滋养层干细胞（TSC）共同培养可以概括这一过程，形成类似胚胎的结构。但是，驱动ESC-TSC相互作用的机制仍然难以捉摸。我们描述了与TSC分泌Wnts反应的专业ESC生成的细胞因子。胞浆形成和长度受肌动蛋白，细胞内...