Background

Although the clinical hair changes that occur under treatment with epidermal growth factor receptor inhibitors (EGFRIs) are documented, their trichoscopic features have not been reported.

Objective

To evaluate the trichoscopic findings in scalp and facial hair, induced by EGFRI treatment.

Methods

Patients treated with EGFRIs at a tertiary oncodermatology clinic in 2015 through 2017 were evaluated for macroscopic and trichoscopic changes.

Results

The cohort included 23 patients (13 women; median age, 68 years) treated with EGFRIs for an average of 13 months (range, 2-40 months). Macroscopically, 18 patients (78%) had dry, lusterless, coarse, kinky, brittle scalp hair, and 17 (74%) had trichomegaly of the eyebrows/eyelashes. Trichoscopic findings were of hair shaft anomalies including pili torti, affecting scalp hair in 20 patients (87%), eyebrows in 6 (26%), and eyelashes in 8 (50%), and asymmetric hyperpigmented fusiform widening of hair scalp in 3 (13%), eyebrows in 10 (43%), and eyelashes in 4 (25%). Dermoscopic findings of the peri- and interfollicular skin were scale, whitish erythematous structureless areas, and branching vessels.

Limitations

Lack of trichoscopic-histologic correlation, lack of baseline examination.

Conclusion

The trichoscopic correlates of the macroscopic hair changes under EFGRI treatment include pili torti, and asymmetric hyperpigmented fusiform widening, with dermoscopic cutaneous manifestations of scale, whitish erythematous structureless areas, and branching vessels.

中文翻译：

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表皮生长因子受体抑制剂诱发毛干异常的毛细镜特征：病例系列

背景

尽管记录了在表皮生长因子受体抑制剂 (EGFRIs) 治疗下发生的临床毛发变化，但尚未报道其毛发镜特征。

客观的

评估由 EGFRI 治疗诱导的头皮和面部毛发中的毛发检查结果。

方法

对 2015 年至 2017 年在一家三级肿瘤诊所接受 EGFRRI 治疗的患者进行了宏观和毛镜变化评估。

结果

该队列包括 23 名患者（13 名女性；中位年龄，68 岁），接受 EGFRIs 治疗平均 13 个月（范围，2-40 个月）。宏观上，18 名患者（78%）有干燥、无光泽、粗糙、卷曲、易碎的头皮毛发，17 名（74%）有眉毛/睫毛多毛症。毛干镜检查结果包括毛干异常，包括 20 名患者 (87%) 的头皮毛发、6 名 (26%) 的眉毛和 8 名 (50%) 的睫毛，以及 3 名头皮的不对称色素沉着性梭形增宽。 13%)，眉毛 10 个 (43%)，睫毛 4 个 (25%)。皮肤镜检查发现毛囊周围和滤泡间皮肤有鳞屑、发白的红斑无结构区域和分支血管。

限制

缺乏毛镜组织学相关性，缺乏基线检查。

结论

在 EFGRI 治疗下，毛发宏观变化的毛镜相关性包括毛囊和不对称的色素沉着过度梭形增宽，皮肤镜下皮肤表现有鳞屑、发白的红斑无结构区域和分支血管。