Relevance and proteomics challenge of functional posttranslational modifications in Kinetoplastid parasites.,Journal of Proteomics

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Relevance and proteomics challenge of functional posttranslational modifications in Kinetoplastid parasites.
Journal of Proteomics ( IF 2.8 ) Pub Date : 2020-03-31 , DOI: 10.1016/j.jprot.2020.103762
R Manzano-Román ₁ , M Fuentes ₂

Affiliation

Protozoan parasitic infections are health, social and economic issues impacting both humans and animals, with significant morbidity and mortality worldwide. Protozoan parasites have complicated life cycles with both intracellular and extracellular forms. As a consequence, protozoan adapt to changing environments in part through a dynamic enzyme-catalyzed process leading to reversible posttranslational modifications (PTMs). The characterization by proteomics approaches reveals the critical role of the PTMs of the proteins involved in host-pathogen interaction. The complexity of PTMs characterization is increased by the high diversity, stoichiometry, dynamic and also co-existence of several PTMs in the same moieties which crosstalk between them. Here, we review how to understand the complexity and the essential role of PTMs crosstalk in order to provide a new hallmark for vaccines developments, immunotherapies and personalized medicine. In addition, the importance of these motifs in the biology and biological cycle of kinetoplastid parasites is highlighted with key examples showing the potential to act as targets against protozoan diseases.

中文翻译：

相关性和蛋白质组学挑战的运动质体寄生虫的功能翻译后修饰。

原生动物的寄生虫感染是影响人类和动物的健康，社会和经济问题，在世界范围内都有很高的发病率和死亡率。原生动物寄生虫具有复杂的生命周期，具有细胞内和细胞外的形式。结果，原生动物部分地通过动态酶催化过程适应变化的环境，从而导致可逆的翻译后修饰（PTM）。蛋白质组学方法的表征揭示了参与宿主-病原体相互作用的蛋白质的PTM的关键作用。PTM表征的复杂性因其相互串扰的同一部分中的多个PTM的高度多样性，化学计量，动态以及共存而增加。这里，我们回顾了如何理解PTM串扰的复杂性和基本作用，以便为疫苗开发，免疫疗法和个性化医学提供新的标志。此外，这些关键特征在动质体寄生虫的生物学和生物学循环中的重要性得到了突出显示，其中的关键实例表明了其有可能成为对抗原生动物疾病的靶标。

更新日期：2020-03-31

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