当前位置：
X-MOL 学术
›
Environ. Pollut.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Associations between selected perfluoroalkyl acids in serum and hemoglobin in whole blood, a biomarker of anemia: Impact of deteriorating kidney function.
Environmental Pollution ( IF 7.6 ) Pub Date : 2020-03-31 , DOI: 10.1016/j.envpol.2020.114458 Ram B Jain 1
Environmental Pollution ( IF 7.6 ) Pub Date : 2020-03-31 , DOI: 10.1016/j.envpol.2020.114458 Ram B Jain 1
Affiliation
|
Data (N = 11251) from National Health and Nutrition Examination Survey (NHANES) for 2003-2016 for US adults aged ≥20 years were stratified by gender and anemia and analyzed to evaluate the associations between the concentrations of whole blood hemoglobin (WBHGB) and selected perfluoroalkyl acids (PFAAs) in serum by stages of glomerular filtration (GF). Investigated PFAAs were perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorodecanoic acid (PFDA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA). Females with whole blood hemoglobin concentrations <12 g/dL and males with whole blood hemoglobin concentrations <13 g/dL were classified as being anemic. Regression models with log10 transformed concentrations of whole blood hemoglobin as dependent variable and age, poverty income ratio, body mass index, serum cotinine, daily alcohol intake, survey year, and log10 concentrations of one of the PFAA as independent variables were fitted. For anemic females, association between WBHGB and PFAA concentrations were uniformly positive across worsening stages of renal failure and percent increases for 10% increases in PFAAs varied between 0.03% and 0.39%. For anemic males, association between WBHGB and PFAA concentrations were positive except at GF-3A (45 ≤ eGFR<60 mL/min/1.73 m2) and percent increases for 10% increases in PFAAs varied between 0.02% and 0.53%. Thus, more often than not, presence of positive associations between WBHGB and PFAA among anemics imply elevated levels of PFAA are associated with higher levels of WBHGB. Similar results were observed for non-anemic males and females, however strengths of associations between whole blood hemoglobin and PFAAs were several fold higher among anemic compared to non-anemic participants. Hemoglobin is consistently associated with serum PFAAs.
中文翻译：
血清中选定的全氟烷基酸与全血中的血红蛋白（贫血的生物标志物）之间的关联：肾脏功能恶化的影响。
根据性别和贫血对2003年至2016年美国20岁以上成年人的美国国家健康和营养调查（NHANES）数据（N = 11251）进行分层，并进行分析以评估全血血红蛋白（WBHGB）浓度与通过肾小球滤过（GF）阶段从血清中选择全氟烷基酸（PFAAs）。研究的PFAA是全氟辛酸（PFOA），全氟辛烷磺酸（PFOS），全氟癸酸（PFDA），全氟己烷磺酸（PFHxS）和全氟壬酸（PFNA）。全血血红蛋白浓度<12 g / dL的女性和全血血红蛋白浓度<13 g / dL的男性被归为贫血。将log10转化的全血血红蛋白浓度作为因变量以及年龄，贫困收入比，拟合体重指数，血清可替宁，每日酒精摄入量，调查年份和一种PFAA作为独立变量的log10浓度。对于贫血女性，在肾衰竭恶化阶段，WBHGB和PFAA浓度之间的相关性均呈正相关，PFAA的增加百分比为10％的增加百分比介于0.03％和0.39％之间。对于贫血男性，除GF-3A（45≤eGFR <60 mL / min / 1.73 m2）外，WBHGB和PFAA浓度之间呈正相关，PFAA的10％增加百分比在0.02％至0.53％之间变化。因此，在流行病学中，WBHGB和PFAA之间存在正向关联通常意味着PFAA的升高与WBHGB的升高有关。对于非贫血的男性和女性，观察到相似的结果，然而，与非贫血参与者相比，贫血中全血血红蛋白与PFAA之间的关联强度要高出几倍。血红蛋白始终与血清PFAA相关。
更新日期：2020-03-31
中文翻译：
血清中选定的全氟烷基酸与全血中的血红蛋白（贫血的生物标志物）之间的关联：肾脏功能恶化的影响。
根据性别和贫血对2003年至2016年美国20岁以上成年人的美国国家健康和营养调查（NHANES）数据（N = 11251）进行分层，并进行分析以评估全血血红蛋白（WBHGB）浓度与通过肾小球滤过（GF）阶段从血清中选择全氟烷基酸（PFAAs）。研究的PFAA是全氟辛酸（PFOA），全氟辛烷磺酸（PFOS），全氟癸酸（PFDA），全氟己烷磺酸（PFHxS）和全氟壬酸（PFNA）。全血血红蛋白浓度<12 g / dL的女性和全血血红蛋白浓度<13 g / dL的男性被归为贫血。将log10转化的全血血红蛋白浓度作为因变量以及年龄，贫困收入比，拟合体重指数，血清可替宁，每日酒精摄入量，调查年份和一种PFAA作为独立变量的log10浓度。对于贫血女性，在肾衰竭恶化阶段，WBHGB和PFAA浓度之间的相关性均呈正相关，PFAA的增加百分比为10％的增加百分比介于0.03％和0.39％之间。对于贫血男性，除GF-3A（45≤eGFR <60 mL / min / 1.73 m2）外，WBHGB和PFAA浓度之间呈正相关，PFAA的10％增加百分比在0.02％至0.53％之间变化。因此，在流行病学中，WBHGB和PFAA之间存在正向关联通常意味着PFAA的升高与WBHGB的升高有关。对于非贫血的男性和女性，观察到相似的结果，然而，与非贫血参与者相比，贫血中全血血红蛋白与PFAA之间的关联强度要高出几倍。血红蛋白始终与血清PFAA相关。
京公网安备 11010802027423号