Guava leaf flavonoids were obtained using a simple extraction method to evaluate their anti-hyperglycemic and liver protective effects with a high-fat diet and a low-dose streptozotocin induced diabetic mouse model. Flavonoids supplementation significantly decreased fasting plasma glucose, glucose tolerance, and the insulin resistance index in diabetic mice, lowered the serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol compared to the diabetic control group (p < 0.05). Furthermore, guava leaf flavonoids significantly decreased the liver and kidney indexes, and improved hepatocyte morphology in diabetic mice. Taken together, these results showed that guava leaf flavonoids had significant anti-diabetic and liver protective activities in diabetic mice. This study could facilitate the development of hypoglycemic functional foods from guava leaves.

使用简单的提取方法获得番石榴叶黄酮，以评估其在高脂饮食和低剂量链脲佐菌素诱导的糖尿病小鼠模型中的抗高血糖和肝脏保护作用。与糖尿病对照组相比，补充类黄酮显着降低了糖尿病小鼠的空腹血糖，葡萄糖耐量和胰岛素抵抗指数，降低了血清总胆固醇，三酰甘油和低密度脂蛋白胆固醇（p <0.05）。此外，番石榴叶类黄酮显着降低了糖尿病小鼠的肝肾指标，并改善了肝细胞的形态。综上所述，这些结果表明番石榴叶类黄酮在糖尿病小鼠中具有显着的抗糖尿病和肝脏保护活性。