The loop extrusion hypothesis postulated that extrusion of DNA loops through cohesin rings organizes genomes. Recent findings suggest that cohesin itself is a molecular motor that extrudes DNA. This has important implications not only for the organization of interphase chromatin but also for other processes where cohesin plays vital roles.

中文翻译：

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粘连蛋白生物学：从被动环到分子马达。


环挤出假说假设 DNA 环通过粘连环挤出来组织基因组。最近的研究结果表明，粘连蛋白本身就是一种挤出 DNA 的分子马达。这不仅对间期染色质的组织具有重要意义，而且对粘连蛋白发挥重要作用的其他过程也具有重要意义。