Antibacterial scaffolds are highly desirable for the repair and reconstruction of injured soft tissues. However, the direct fabrication of scaffolds with excellent biocompatibility, flexibility, and antibacterial capacity remains a challenge, especially those based on biomaterials. In this study, we report the biomaterial-based antibacterial scaffolds based on regenerated silk fibroin, 2-hydroxypropyltrimethyl ammonium chloride chitosan, and bladder acellular matrix graft by blend and coaxial electrospinning. This approach eliminated the use of organic solvents and inorganic nanoparticles, ensuring greater clinical safety, mimicking physiological extracellular matrix structures, and the required softness for a suture material. Thus, the scaffold obtained in this study exhibited excellent biocompatibility, the required mechanical characteristics, and excellent antibacterial capacity. The rate of bacterial elimination of Staphylococcus aureus and Escherichia coli reached up to 99.5 and 98.3%, respectively. The scaffold design favored cell growth and proliferation and resulted in the significant promotion of repair and reconstruction of the urethra, indicating that it can be an ideal antibacterial suture material for soft tissue restoration.

中文翻译：

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基于生物材料的支架作为抗菌缝合材料

对于修复和重建受伤的软组织，非常需要抗菌支架。然而，直接制造具有优异的生物相容性，柔韧性和抗菌能力的支架仍然是一个挑战，特别是那些基于生物材料的支架。在这项研究中，我们报告了基于生物材料的抗菌支架，该支架基​​于再生丝素蛋白，2-羟丙基三甲基氯化铵壳聚糖和通过混合和同轴静电纺丝的膀胱脱细胞基质移植。这种方法消除了有机溶剂和无机纳米粒子的使用，确保了更高的临床安全性，模仿了生理学的细胞外基质结构，以及缝合材料所需的柔软性。因此，本研究中获得的支架具有出色的生物相容性，所需的机械特性，和出色的抗菌能力。细菌清除率金黄色葡萄球菌和大肠杆菌分别达到了99.5％和98.3％。支架设计有利于细胞生长和增殖，并显着促进了尿道的修复和重建，表明它可以作为软组织修复的理想抗菌缝合材料。